Chloramphenicol + Lidocaine Hydrochloride
Generic / Active Ingredient
What is Chloramphenicol + Lidocaine Hydrochloride used for?
Otic infections
3 Chloramphenicol + Lidocaine Hydrochloride brands in Bangladesh
Compare prices across every brand of Chloramphenicol + Lidocaine Hydrochloride and pick the most affordable option.
| Brand | Strength | Form | Manufacturer | Price |
|---|---|---|---|---|
| Chlorphen | 5%+1% | Ear Drop | Nipa Pharmaceuticals Ltd. | ৳ 20.23 |
| OTO-Plus | 5%+1% | Ear Drop | Edruc Limited | ৳ 20.00 |
| Supraphen plus | 5%+1% | Ear Drop | Gaco Pharmaceuticals Ltd. | ৳ 20.06 |
Indication DetailsView
Acute bacterial ear infections
Therapeutic ClassView
Aural Anti-bacterial preparations
PharmacologyView
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
DosageView
Otic/Aural Otitis externa: Instill 2-3 drops into the ear bid-tid.
Side EffectsView
Ototoxicity.
ContraindicationsView
History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.
PrecautionsView
Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.
InteractionsView
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
Pregnancy & LactationView
Pregnancy Category C & B. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.