Diflu

For the treatment of fungal corneal ulcers/ keratitis.

Ophthalmic Anti-fungal Products

Fluconazole is fungistatic in action. It inhibits cytochrome P-450 14-α demethylase in susceptible fungi which leads to accumulation of lanosterol and decreased concentration of ergosterol thereby altering cellular membrane resulting in increased membrane permeability, leakage of essential elements and impaired uptake of precursor molecules to DNA.

Instill 1 drop to be instilled into the affected eye(s) 5 times daily.

This drug is generally well tolerated. Eosinophillia has been reported in some patients.

The drug is contraindicated in patients with hypersensitivity to azoles.

Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than Candida albicans

Fluconazole can alter pharmacokinetics of certain drugs undergoing hepatic metabolism.

Use in pregnancy: Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Fluconazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: Nursing mother should not be given as the drug is excreted in breast milk in concentration similar to plasma.

Keep out of the reach of children. Store in a cool, dry place, away from heat and direct light. Do not use more than 4 weeks after opening the bottle