Azisan Plus
Azilsartan Medoxomil + Chlorthalidone → (2 brands)
Unit Price
৳ 22.00
10's pack৳ 220.00
Unit Price৳ 22.00
20's pack৳ 440.00
(10's pack: ৳ 220.00),(20's pack: ৳ 440.00)
Renata Limited
Drug Class
Combined antihypertensive preparations
Indication
Stroke
Dosage Form
Tablet
Manufacturer
Renata Limited
Compare Alternate Brands
Same generic (Azilsartan Medoxomil + Chlorthalidone), 40 mg+12.5 mg, Tablet — 1 alternate brand available.
Indication DetailsView
For the treatment of hypertension, to lower blood pressure:
- In patients not adequately controlled with ARB monotherapy
- As initial therapy in patients likely to need multiple drugs to help
Therapeutic ClassView
Combined antihypertensive preparations
PharmacologyView
Azilsartan medoxomil is an angiotensin II receptor blocker (ARB). Azilsartan helps blood vessels to dilate. It also helps to excrete of Sodium and water from body. This combination also contains a diuretic. Chlorthalidone works in the kidneys to flush excess water and salt (sodium) from the body. Together, these 2 medicines work to help lower blood pressure in people who need more than 1 medicine to treat their high blood pressure (hypertension).
DosageView
The recommended starting dose is 40/12.5 mg taken orally once daily. Most of the antihypertensive effect is apparent within 1 to 2 weeks. This combination may be used to provide additional blood pressure lowering for patients not adequately controlled on ARB or diuretic monotherapy treatment. Patients not controlled with azilsartan medoxomil 80 mg may have an additional systolic/diastolic clinic blood pressure reduction of 13/6 mm Hg when switched to this combination 40/12.5 mg.
This combination may be used as initial therapy if a patient is likely to need multiple drugs to achieve blood pressure goals. Patients titrated to the individual components (azilsartan medoxomil and chlorthalidone) may instead receive the corresponding dose of This combination.
This combination may be used as initial therapy if a patient is likely to need multiple drugs to achieve blood pressure goals. Patients titrated to the individual components (azilsartan medoxomil and chlorthalidone) may instead receive the corresponding dose of This combination.
Side EffectsView
The following potential adverse reactions are-
- Fetal toxicity
- Hypotension in Volume- or Salt-Depleted Patients
- Impaired Renal Function
- Hypokalemia Hyperuricemia
ContraindicationsView
This is contraindicated in patients with anuria.
PrecautionsView
- In patients with an activated renin-angiotensin-aldosterone system (RAAS), such as volume- and/or salt-depleted patients, this combination can cause excessive hypotension. Correct volume or salt depletion prior to administration of azilsartan and chlorthalidone.
- In patients with renal artery stenosis, This combination may cause renal failure.
- Monitor renal function in patients with renal impairment. Consider discontinuing this combination with progressive renal impairment.
- Heart rhythm problems (e.g., bradycardia, QT prolongation, ventricular tachycardia), liver problems, certain uncorrected mineral imbalances (low potassium/magnesium levels), severe kidney problems.
InteractionsView
Renal clearance of lithium is reduced by diuretics, such as chlorthalidone increasing the risk of lithium toxicity. NSAIDs increase risk of renal dysfunction and interfere with antihypertensive effect
Pregnancy & LactationView
Pregnancy Category D. Use of drugs that affect the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
Storage ConditionsView
Store in a cool & dry place, away from light and children.