Medicines

Find Medicines

Search 21,000+ medicines by brand, generic, indication, or drug class

Medicine Indications Drug Classes
    Showing all medicines (21591 total)

    Nervent

    Jadwar [Denudatum, Saffron, Henbane]
    Tablet Herbal Herbal and Nutraceuticals

    Indications

    Premature ejaculation

    Indication detailsView
    This is indicated in-
    • Nervous debility
    • Depression
    • Premature ejaculation
    • General debility
    • Chronic Cold
    • Catarrh & cough
    Therapeutic classView
    Herbal and Nutraceuticals
    PharmacologyView
    This is a unique combination of Denudatum (Delphinium denudatum), Saffron (Crocus sativus), Clove (Eugenia caryophyllus), Castorium and other natural ingredients. It is highly effective in nervous debility and acts as an ideal aphrodisiac. This is also useful in the treatment of general debility, chronic cold & cough.
    DosageView
    1-2 tablet(s) twice daily before meal or as prescribed by the physician.
    Side effectsView
    No significant side effect has been observed in proper dosage.
    ContraindicationsView
    There is no known contraindication.
    PrecautionsView
    Keep out of reach of the children.
    StorageView
    Store at cool and dry place, protect from light.

    Nervex

    Mecobalamin
    Tablet 500 mcg Allopathic Drugs for Megaloblastic Anemia

    Indications

    Peripheral neuropathy

    Indication detailsView
    Mecobalamin is indicated in-
    • Peripheral Neuropathies
    • Diabetic Neuropathy
    • Verteberal Syndrome
    • Nerve Compression Syndrome
    • Multiple sclerosis
    • Amyotrophic lateral sclerosis
    • Parkinson’s disease
    • Alzheimer’s disease
    • Diabetic retinopathy
    • Entrapment neuropathy
    • Drug induced neuropathy
    • Megaloblastic anemia due to Vitamin B12 deficiency
    Therapeutic classView
    Drugs for Megaloblastic Anemia
    PharmacologyView
    Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
    DosageView
    Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms. 

    Injection:
    • Peripheral neuropathies: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms. 
    • Megaloblastic anemia: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy
    Side effectsView
    Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.
    ContraindicationsView
    Hypersensitivity to any component of this product.
    PrecautionsView
    The medicine should not be used for months if there is no response at all after its use for a certain period of time.
    InteractionsView
    Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
    Pregnancy & lactationView
    Not recommended during pregnancy & lactation.
    Pediatric usageView
    Use in children: Not recommended.
    StorageView
    Oral: Store at room temperature. Protect from moisture and light.
    Parenteral: Store at room temperature. Do not expose to direct light.

    Nervin

    Vitamin B1, B2 & B6
    Injection (100 mg+50 mg+100 mg)/2 ml Allopathic Specific combined vitamin preparations

    Indications

    Vitamin B deficiencies

    Indication detailsView
    It is indicated for supportive nutritional supplementation in conditions in which these vitamins are required. These include conditions causing depletion, or reduced absorption or bioavailability of vitamins such as gastrointestinal disorders, chronic alcoholism, febrile illness, prolonged or wasting diseases, hyperthyroidism or poorly controlled diabetes and conditions resulting in increased need for vitamins like pregnancy, severe burns, recovery from surgery. It is also used in beri-beri, peripheral neuritis, Wernicke’s encephalopathy, impaired digestion of starch and sugar due to thiamine deficiency, cheilosis, angular stomatitis, glossitis, keratitis, seborrhoeic dermatitis, photophobia and corneal vascularization.
    Therapeutic classView
    Specific combined vitamin preparations, Vitamin-B preparations
    PharmacologyView
    Thiamine (Vitamin B1) forms thiamine pyrophosphate by combining with adenosine triphosphate; essential coenzyme in carbohydrate metabolism.

    Riboflavin     (vitamin B2) is required for energy utilisation from food. It is essential for normal tissue respiration. It is also necessary for the activation of pyridoxine and conversion of tryptophan to nicotinic acid.

    Pyridoxine     (vitamin B6) is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
    DosageView
    Adults: 2 ml every day or alternate days intravenously or intramuscularly.
    Side effectsView
    Adverse reactions have been reported with specific vitamins, and generally at levels substantially higher than those in Vitamin B1, B2 & B6. However, allergic and idiosyncratic reactions are possible at lower levels.
    ContraindicationsView
    Hypersensitivity to any of its components.
    PrecautionsView
    It should be given cautiously to patients taking levodopa as pyridoxine reduces the effect of levodopa. Hypersensitivity may develop in patients previously given thiamine, specially after repeated injections of concentrated solution; give subsequent injections with care. Discontinue drug if untoward reactions develop. Intramuscular administration may cause transient pain; when used undiluted, administer slowly.
    InteractionsView
    Pyridoxine may increase the peripheral metabolism of levodopa, reducing therapeutic efficacy in patients with Parkinson’s disease.
    Pregnancy & lactationView
    The recommended dose should not be exceeded without medical advice.
    StorageView
    Store below 25°C in a dry place, away from light.

    Nerviplex

    Vitamin B1, B6 & B12
    IM Injection (100 mg+100 mg+1 mg)/3 ml Allopathic Specific combined vitamin preparations

    Indications

    Vitamin B deficiencies

    Indication detailsView
    Vitamin B1, B6 & B12 is indicated for the treatment of vitamin B1, B6 & B12 deficiency syndrome. It is also indicated for the supportive treatment of neuritis & non-inflammatory diseases of the nerves, e.g.- Diabetic neuropathy, Peripheral neuralgin, Lumbago, Myalgia, Optic neuritis, Sciatica, Facial neuralgia, Intercostal neuralgia, Spinal pain.
    Therapeutic classView
    Specific combined vitamin preparations
    PharmacologyView
    Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression and eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness, tingling and lowers the risk of heart diseases.

    The vitamin ingredients are absorbed well in per oral reception. It is widely distributed to most tissues and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.
    DosageView
    Tablet: 1-3 Tablets per day or as advised by the physician.

    Injection:
    • In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
    • In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.
    Use in children: There is no information on the use of this drug in children.
    Side effectsView
    Generally well tolerated but allergic reactions may be observed in few cases.
    ContraindicationsView
    Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.
    PrecautionsView
    Cyanocobalamin should not be given in patients with subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.
    InteractionsView
    No drug interaction has been reported yet.
    Pregnancy & lactationView
    Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy & lactation.
    Overdose effectsView
    No overdosage symptoms are to be expected in the recommended dosage. If there is known overdose then treatment is symptomatic & supportive.
    StorageView
    Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

    Nerviplex

    Vitamin B1, B6 & B12
    Tablet 100 mg+200 mg+200 mcg Allopathic Specific combined vitamin preparations

    Indications

    Vitamin B deficiencies

    Indication detailsView
    Vitamin B1, B6 & B12 is indicated for the treatment of vitamin B1, B6 & B12 deficiency syndrome. It is also indicated for the supportive treatment of neuritis & non-inflammatory diseases of the nerves, e.g.- Diabetic neuropathy, Peripheral neuralgin, Lumbago, Myalgia, Optic neuritis, Sciatica, Facial neuralgia, Intercostal neuralgia, Spinal pain.
    Therapeutic classView
    Specific combined vitamin preparations
    PharmacologyView
    Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression and eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness, tingling and lowers the risk of heart diseases.

    The vitamin ingredients are absorbed well in per oral reception. It is widely distributed to most tissues and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.
    DosageView
    Tablet: 1-3 Tablets per day or as advised by the physician.

    Injection:
    • In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
    • In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.
    Use in children: There is no information on the use of this drug in children.
    Side effectsView
    Generally well tolerated but allergic reactions may be observed in few cases.
    ContraindicationsView
    Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.
    PrecautionsView
    Cyanocobalamin should not be given in patients with subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.
    InteractionsView
    No drug interaction has been reported yet.
    Pregnancy & lactationView
    Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy & lactation.
    Overdose effectsView
    No overdosage symptoms are to be expected in the recommended dosage. If there is known overdose then treatment is symptomatic & supportive.
    StorageView
    Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

    Nerviton

    Mecobalamin
    IM/IV Injection 500 mcg/ml Allopathic Drugs for Megaloblastic Anemia

    Indications

    Peripheral neuropathy

    Indication detailsView
    Mecobalamin is indicated in-
    • Peripheral Neuropathies
    • Diabetic Neuropathy
    • Verteberal Syndrome
    • Nerve Compression Syndrome
    • Multiple sclerosis
    • Amyotrophic lateral sclerosis
    • Parkinson’s disease
    • Alzheimer’s disease
    • Diabetic retinopathy
    • Entrapment neuropathy
    • Drug induced neuropathy
    • Megaloblastic anemia due to Vitamin B12 deficiency
    Therapeutic classView
    Drugs for Megaloblastic Anemia
    PharmacologyView
    Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
    DosageView
    Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms. 

    Injection:
    • Peripheral neuropathies: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms. 
    • Megaloblastic anemia: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy
    Side effectsView
    Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.
    ContraindicationsView
    Hypersensitivity to any component of this product.
    PrecautionsView
    The medicine should not be used for months if there is no response at all after its use for a certain period of time.
    InteractionsView
    Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
    Pregnancy & lactationView
    Not recommended during pregnancy & lactation.
    Pediatric usageView
    Use in children: Not recommended.
    StorageView
    Oral: Store at room temperature. Protect from moisture and light.
    Parenteral: Store at room temperature. Do not expose to direct light.

    Nerviton

    Mecobalamin
    Tablet 500 mcg Allopathic Drugs for Megaloblastic Anemia

    Indications

    Peripheral neuropathy

    Indication detailsView
    Mecobalamin is indicated in-
    • Peripheral Neuropathies
    • Diabetic Neuropathy
    • Verteberal Syndrome
    • Nerve Compression Syndrome
    • Multiple sclerosis
    • Amyotrophic lateral sclerosis
    • Parkinson’s disease
    • Alzheimer’s disease
    • Diabetic retinopathy
    • Entrapment neuropathy
    • Drug induced neuropathy
    • Megaloblastic anemia due to Vitamin B12 deficiency
    Therapeutic classView
    Drugs for Megaloblastic Anemia
    PharmacologyView
    Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
    DosageView
    Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms. 

    Injection:
    • Peripheral neuropathies: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms. 
    • Megaloblastic anemia: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy
    Side effectsView
    Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.
    ContraindicationsView
    Hypersensitivity to any component of this product.
    PrecautionsView
    The medicine should not be used for months if there is no response at all after its use for a certain period of time.
    InteractionsView
    Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
    Pregnancy & lactationView
    Not recommended during pregnancy & lactation.
    Pediatric usageView
    Use in children: Not recommended.
    StorageView
    Oral: Store at room temperature. Protect from moisture and light.
    Parenteral: Store at room temperature. Do not expose to direct light.

    Nervolin

    Aswagandharista
    Syrup Herbal Herbal and Nutraceuticals

    Indications

    Libido

    Indication detailsView
    This is indicaed in Nervous debility, Reduce libido, Insanity, Insomnia, Swooning (Syncope) & General decay.
    Therapeutic classView
    Herbal and Nutraceuticals
    PharmacologyView
    Withania somnifera: It is sedative, tonic, stimulant, aphrodisiac, adaptogenic & alterative. It restores loss of memory and is used in cases of nervous exhaustion, spermatorrhoea and senile debility. In modern research, it has been compared to Panax ginseng for its endurance-enhancing properties. This is considering being an important vajikaron drug, capable of promoting the semen and sexual vigor.

    Curculigo orchioides: Musali is a reputed rasayan (rejuvenative) drug and a good aphrodisiac medicine. It improves complexion and is useful in general debility & impotence.

    Vanda roxburghii: The root is used in bronchitis, rheumatism & nervine weakness. Charaka recommend rasna in maintaining the youthful vigor and strength.

    Ipoema paniculata: It is aphrodisiac, alterative, sweet, cooling, restorative & tonic. It is used to increase weight reduced due to mental & physical fatigue. The drug is recommended in all cases of general debility and rheumatism.
    DosageView
    Adult: 2-4 teaspoonful 2-3 times daily after meal
    Children: 1-2 teaspoonful 2-3 times daily after meal or as prescribed by the physician.
    Side effectsView
    There is no significant side effect.
    ContraindicationsView
    There is no absolute contraindication.
    Pregnancy & lactationView
    No restriction known.
    StorageView
    Store in a cool & dry place, protected from light. Keep all medicines out of reach of children.

    Nervopex

    Vitamin B1, B6 & B12
    Tablet 100 mg+200 mg+200 mcg Allopathic Specific combined vitamin preparations

    Indications

    Vitamin B deficiencies

    Indication detailsView
    Vitamin B1, B6 & B12 is indicated for the treatment of vitamin B1, B6 & B12 deficiency syndrome. It is also indicated for the supportive treatment of neuritis & non-inflammatory diseases of the nerves, e.g.- Diabetic neuropathy, Peripheral neuralgin, Lumbago, Myalgia, Optic neuritis, Sciatica, Facial neuralgia, Intercostal neuralgia, Spinal pain.
    Therapeutic classView
    Specific combined vitamin preparations
    PharmacologyView
    Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression and eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness, tingling and lowers the risk of heart diseases.

    The vitamin ingredients are absorbed well in per oral reception. It is widely distributed to most tissues and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.
    DosageView
    Tablet: 1-3 Tablets per day or as advised by the physician.

    Injection:
    • In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
    • In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.
    Use in children: There is no information on the use of this drug in children.
    Side effectsView
    Generally well tolerated but allergic reactions may be observed in few cases.
    ContraindicationsView
    Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.
    PrecautionsView
    Cyanocobalamin should not be given in patients with subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.
    InteractionsView
    No drug interaction has been reported yet.
    Pregnancy & lactationView
    Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy & lactation.
    Overdose effectsView
    No overdosage symptoms are to be expected in the recommended dosage. If there is known overdose then treatment is symptomatic & supportive.
    StorageView
    Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

    Nescom

    Naproxen Sodium + Esomeprazole Magnesium
    Tablet (Delayed Release) 500 mg+20 mg Allopathic Drugs for Osteoarthritis

    Indications

    Systemic lupus erythematosus (SLE)

    Indication detailsView
    Naproxen & Esomeprazole is indicated for the relief of signs & symptoms of-
    • Osteoarthritis
    • Rheumatoid arthritis
    • Ankylosing spondylitis &
    • To decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
    Therapeutic classView
    Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
    PharmacologyView
    This consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.

    Naproxen is a NSAID with analgesic & antipyretic properties. The mechanism of action of Naproxen is to inhibit the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell by acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
    DosageView
    Carefully consider the potential benefits & risks of this tablet & other treatment options before deciding to use this tablet. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

    Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis-
    • Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older-
    • Weight greater than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    • Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.
    AdministrationView
    Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
    Side effectsView
    In general, this preparation is well tolerated. The most common adverse reactions in clinical trials (>5%): erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea etc.
    ContraindicationsView
    • Known hypersensitivity to any component of this tablet or substituted benzimidazoles.
    • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs.
    • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery.
    PrecautionsView
    Patients with known CV disease/risk factors may be at greater risk. This tablet should be used with caution in patients with fluid retention or heart failure.
    InteractionsView
    With medicine:
    • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
    • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication.
    • Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg. Ketoconazole, iron salts and digoxin).
    With food & others: Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%
    Pregnancy & lactationView
    Pregnancy category C. In late pregnancy, it should be avoided because it may cause premature closure of the ductus arteriosus. This tablet should not be used in nursing mothers due to the Naproxen component.
    Pediatric usageView
    Elderly patients: Studies indicate that although the total plasma concentration of naproxen is unchanged, the unbound plasma fraction of naproxen is increased in the elderly. Use caution when high doses are required & some adjustment of dosage may be required in elderly patients. As with other drugs used in the elderly use the lowest effective dose.

    Patients with Moderate to Severe Renal impairment: Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment (creatinine clearance <30 ml/min).

    Hepatic insufficiency: Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction based on the Naproxen component of this tablet. This is not recommended in patients with severe hepatic impairment because Esomeprazole dosage should not exceed 20 mg daily in these patients.
    Overdose effectsView
    There is no clinical data on overdosage with this tablet.

    Overdose of Naproxen: Significant naproxen overdosage may be characterized by lethargy, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alteration in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, vomiting etc.

    Overdose of Esomeprazole: The major signs of acute toxicity were reduced motor activity, changes in respiratory frequency, tremor and intermittent clonic convulsions etc.
    StorageView
    Store at temperature of below 30°C, protect from light & moisture. Keep out of reach of children.

    Nesifin

    Magnesium Hydroxide + Liquid Paraffin
    Oral Emulsion (300 mg+1.25 ml)/5 ml Allopathic Antacid with laxative action

    Indications

    Constipation

    Indication detailsView
    This preparation is indicated in-
    • Constipation
    • Hyperacidity with constipation
    • Anorectal disorder
    • Post-operative constipation
    • Constipation associated with chronic cholecystitis
    • Hernia
    Therapeutic classView
    Antacid with laxative action
    PharmacologyView
    This preparation has a dual-relief formulation containing a gentle laxative ingredient and a lubricant which eases the discomfort associated with straining and bowel movement. It is recommended for the temporary relief of constipation
    DosageView
    The recommended oral dose are as follows-
    Adults: 15-30ml before breakfast or at bedtime.

    Children:
    • Over 7 years: 7.5 ml-15 ml at bedtime.
    • 3-7 years: 5-10 ml at bedtime.
    The dose may be mixed with milk or half a glass of water if desired. Don't take for more than 1 week unless under doctor's supervision
    Side effectsView
    Rectal irritation, potassium loss (thirst, weakness, nausea and diarrhea).
    ContraindicationsView
    Acute Gl conditions like abdominal pain.
    PrecautionsView
    Renal and hepatic impairment. Maintain adequate fluid intake.
    InteractionsView
    Cimetidine, Diuretics, Famotidine and Ranitidine may cause irritation of stomach or bowel.
    Pregnancy & lactationView
    Can be given to pregnant and lactating mother.
    Overdose effectsView
    There are no reported cases of overdosage.
    StorageView
    Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

    Neso

    Naproxen Sodium + Esomeprazole Magnesium
    Tablet (Delayed Release) 500 mg+20 mg Allopathic Drugs for Osteoarthritis

    Indications

    Systemic lupus erythematosus (SLE)

    Indication detailsView
    Naproxen & Esomeprazole is indicated for the relief of signs & symptoms of-
    • Osteoarthritis
    • Rheumatoid arthritis
    • Ankylosing spondylitis &
    • To decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
    Therapeutic classView
    Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
    PharmacologyView
    This consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.

    Naproxen is a NSAID with analgesic & antipyretic properties. The mechanism of action of Naproxen is to inhibit the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell by acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
    DosageView
    Carefully consider the potential benefits & risks of this tablet & other treatment options before deciding to use this tablet. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

    Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis-
    • Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older-
    • Weight greater than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    • Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.
    AdministrationView
    Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
    Side effectsView
    In general, this preparation is well tolerated. The most common adverse reactions in clinical trials (>5%): erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea etc.
    ContraindicationsView
    • Known hypersensitivity to any component of this tablet or substituted benzimidazoles.
    • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs.
    • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery.
    PrecautionsView
    Patients with known CV disease/risk factors may be at greater risk. This tablet should be used with caution in patients with fluid retention or heart failure.
    InteractionsView
    With medicine:
    • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
    • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication.
    • Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg. Ketoconazole, iron salts and digoxin).
    With food & others: Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%
    Pregnancy & lactationView
    Pregnancy category C. In late pregnancy, it should be avoided because it may cause premature closure of the ductus arteriosus. This tablet should not be used in nursing mothers due to the Naproxen component.
    Pediatric usageView
    Elderly patients: Studies indicate that although the total plasma concentration of naproxen is unchanged, the unbound plasma fraction of naproxen is increased in the elderly. Use caution when high doses are required & some adjustment of dosage may be required in elderly patients. As with other drugs used in the elderly use the lowest effective dose.

    Patients with Moderate to Severe Renal impairment: Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment (creatinine clearance <30 ml/min).

    Hepatic insufficiency: Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction based on the Naproxen component of this tablet. This is not recommended in patients with severe hepatic impairment because Esomeprazole dosage should not exceed 20 mg daily in these patients.
    Overdose effectsView
    There is no clinical data on overdosage with this tablet.

    Overdose of Naproxen: Significant naproxen overdosage may be characterized by lethargy, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alteration in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, vomiting etc.

    Overdose of Esomeprazole: The major signs of acute toxicity were reduced motor activity, changes in respiratory frequency, tremor and intermittent clonic convulsions etc.
    StorageView
    Store at temperature of below 30°C, protect from light & moisture. Keep out of reach of children.

    Neso

    Naproxen Sodium + Esomeprazole Magnesium
    Tablet (Delayed Release) 375 mg+20 mg Allopathic Drugs for Osteoarthritis

    Indications

    Systemic lupus erythematosus (SLE)

    Indication detailsView
    Naproxen & Esomeprazole is indicated for the relief of signs & symptoms of-
    • Osteoarthritis
    • Rheumatoid arthritis
    • Ankylosing spondylitis &
    • To decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
    Therapeutic classView
    Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
    PharmacologyView
    This consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.

    Naproxen is a NSAID with analgesic & antipyretic properties. The mechanism of action of Naproxen is to inhibit the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell by acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
    DosageView
    Carefully consider the potential benefits & risks of this tablet & other treatment options before deciding to use this tablet. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

    Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis-
    • Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older-
    • Weight greater than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    • Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.
    AdministrationView
    Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
    Side effectsView
    In general, this preparation is well tolerated. The most common adverse reactions in clinical trials (>5%): erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea etc.
    ContraindicationsView
    • Known hypersensitivity to any component of this tablet or substituted benzimidazoles.
    • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs.
    • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery.
    PrecautionsView
    Patients with known CV disease/risk factors may be at greater risk. This tablet should be used with caution in patients with fluid retention or heart failure.
    InteractionsView
    With medicine:
    • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
    • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication.
    • Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg. Ketoconazole, iron salts and digoxin).
    With food & others: Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%
    Pregnancy & lactationView
    Pregnancy category C. In late pregnancy, it should be avoided because it may cause premature closure of the ductus arteriosus. This tablet should not be used in nursing mothers due to the Naproxen component.
    Pediatric usageView
    Elderly patients: Studies indicate that although the total plasma concentration of naproxen is unchanged, the unbound plasma fraction of naproxen is increased in the elderly. Use caution when high doses are required & some adjustment of dosage may be required in elderly patients. As with other drugs used in the elderly use the lowest effective dose.

    Patients with Moderate to Severe Renal impairment: Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment (creatinine clearance <30 ml/min).

    Hepatic insufficiency: Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction based on the Naproxen component of this tablet. This is not recommended in patients with severe hepatic impairment because Esomeprazole dosage should not exceed 20 mg daily in these patients.
    Overdose effectsView
    There is no clinical data on overdosage with this tablet.

    Overdose of Naproxen: Significant naproxen overdosage may be characterized by lethargy, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alteration in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, vomiting etc.

    Overdose of Esomeprazole: The major signs of acute toxicity were reduced motor activity, changes in respiratory frequency, tremor and intermittent clonic convulsions etc.
    StorageView
    Store at temperature of below 30°C, protect from light & moisture. Keep out of reach of children.

    Nesotem

    Naproxen Sodium + Esomeprazole Magnesium
    Tablet (Delayed Release) 375 mg+20 mg Allopathic Drugs for Osteoarthritis

    Indications

    Systemic lupus erythematosus (SLE)

    Indication detailsView
    Naproxen & Esomeprazole is indicated for the relief of signs & symptoms of-
    • Osteoarthritis
    • Rheumatoid arthritis
    • Ankylosing spondylitis &
    • To decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
    Therapeutic classView
    Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
    PharmacologyView
    This consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.

    Naproxen is a NSAID with analgesic & antipyretic properties. The mechanism of action of Naproxen is to inhibit the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell by acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
    DosageView
    Carefully consider the potential benefits & risks of this tablet & other treatment options before deciding to use this tablet. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

    Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis-
    • Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older-
    • Weight greater than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    • Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.
    AdministrationView
    Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
    Side effectsView
    In general, this preparation is well tolerated. The most common adverse reactions in clinical trials (>5%): erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea etc.
    ContraindicationsView
    • Known hypersensitivity to any component of this tablet or substituted benzimidazoles.
    • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs.
    • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery.
    PrecautionsView
    Patients with known CV disease/risk factors may be at greater risk. This tablet should be used with caution in patients with fluid retention or heart failure.
    InteractionsView
    With medicine:
    • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
    • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication.
    • Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg. Ketoconazole, iron salts and digoxin).
    With food & others: Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%
    Pregnancy & lactationView
    Pregnancy category C. In late pregnancy, it should be avoided because it may cause premature closure of the ductus arteriosus. This tablet should not be used in nursing mothers due to the Naproxen component.
    Pediatric usageView
    Elderly patients: Studies indicate that although the total plasma concentration of naproxen is unchanged, the unbound plasma fraction of naproxen is increased in the elderly. Use caution when high doses are required & some adjustment of dosage may be required in elderly patients. As with other drugs used in the elderly use the lowest effective dose.

    Patients with Moderate to Severe Renal impairment: Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment (creatinine clearance <30 ml/min).

    Hepatic insufficiency: Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction based on the Naproxen component of this tablet. This is not recommended in patients with severe hepatic impairment because Esomeprazole dosage should not exceed 20 mg daily in these patients.
    Overdose effectsView
    There is no clinical data on overdosage with this tablet.

    Overdose of Naproxen: Significant naproxen overdosage may be characterized by lethargy, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alteration in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, vomiting etc.

    Overdose of Esomeprazole: The major signs of acute toxicity were reduced motor activity, changes in respiratory frequency, tremor and intermittent clonic convulsions etc.
    StorageView
    Store at temperature of below 30°C, protect from light & moisture. Keep out of reach of children.

    Nesotem

    Naproxen Sodium + Esomeprazole Magnesium
    Tablet (Delayed Release) 500 mg+20 mg Allopathic Drugs for Osteoarthritis

    Indications

    Systemic lupus erythematosus (SLE)

    Indication detailsView
    Naproxen & Esomeprazole is indicated for the relief of signs & symptoms of-
    • Osteoarthritis
    • Rheumatoid arthritis
    • Ankylosing spondylitis &
    • To decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
    Therapeutic classView
    Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
    PharmacologyView
    This consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core. As a result, Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.

    Naproxen is a NSAID with analgesic & antipyretic properties. The mechanism of action of Naproxen is to inhibit the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell by acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
    DosageView
    Carefully consider the potential benefits & risks of this tablet & other treatment options before deciding to use this tablet. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

    Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis-
    • Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older-
    • Weight greater than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
    • Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.
    AdministrationView
    Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.
    Side effectsView
    In general, this preparation is well tolerated. The most common adverse reactions in clinical trials (>5%): erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea etc.
    ContraindicationsView
    • Known hypersensitivity to any component of this tablet or substituted benzimidazoles.
    • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs.
    • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery.
    PrecautionsView
    Patients with known CV disease/risk factors may be at greater risk. This tablet should be used with caution in patients with fluid retention or heart failure.
    InteractionsView
    With medicine:
    • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
    • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication.
    • Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg. Ketoconazole, iron salts and digoxin).
    With food & others: Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%
    Pregnancy & lactationView
    Pregnancy category C. In late pregnancy, it should be avoided because it may cause premature closure of the ductus arteriosus. This tablet should not be used in nursing mothers due to the Naproxen component.
    Pediatric usageView
    Elderly patients: Studies indicate that although the total plasma concentration of naproxen is unchanged, the unbound plasma fraction of naproxen is increased in the elderly. Use caution when high doses are required & some adjustment of dosage may be required in elderly patients. As with other drugs used in the elderly use the lowest effective dose.

    Patients with Moderate to Severe Renal impairment: Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment (creatinine clearance <30 ml/min).

    Hepatic insufficiency: Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction based on the Naproxen component of this tablet. This is not recommended in patients with severe hepatic impairment because Esomeprazole dosage should not exceed 20 mg daily in these patients.
    Overdose effectsView
    There is no clinical data on overdosage with this tablet.

    Overdose of Naproxen: Significant naproxen overdosage may be characterized by lethargy, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alteration in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, vomiting etc.

    Overdose of Esomeprazole: The major signs of acute toxicity were reduced motor activity, changes in respiratory frequency, tremor and intermittent clonic convulsions etc.
    StorageView
    Store at temperature of below 30°C, protect from light & moisture. Keep out of reach of children.

    Nestor

    Rosuvastatin
    Tablet 10 mg Allopathic Other Anti-anginal & Anti-ischaemic drugs

    Indications

    Stroke

    Indication detailsView
    Rosuvastatin is indicated in-
    • Heterozygous Hypercholesterolemia (Familial and Non familial)
    • Homozygous Hypercholesterolemia (Familial)
    • Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
    • Primary prevention of cardiovascular disease
    Therapeutic classView
    Other Anti-anginal & Anti-ischaemic drugs, Statins
    PharmacologyView
    Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.
    DosageView
    Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

    HoFH: Starting dose 20 mg/day.

    Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

    Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.
    AdministrationView
    Rosuvastatin can be taken with or without food, at any time of day.
    Side effectsView
    Rosuvastatin is generally well tolerated. The most frequent adverse events thought to be related to Rosuvastatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.
    ContraindicationsView
    Rosuvastatin is contraindicated if-
    • Known hypersensitivity to product components
    • Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
    • Pregnant women and women who may become pregnant
    • Nursing mothers
    PrecautionsView
    Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Rosuvastatin can be discontinued if signs or symptoms appear.

    Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur.

    Liver enzymes should be monitored before and during treatment
    InteractionsView
    Remarkable drug interactions of Rosuvastatin are-
    • Cyclosporine: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be limited to 5 mg once daily.
    • Gemfibrosil: Combination should be avoided. If used together, Rosuvastatin dose should be limited to 10 mg once daily.
    • Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be to 10 mg once daily.
    • Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rosuvastatin. INR should be monitored frequently until stable upon initiation or alteration of Rosuvastatin therapy.
    • Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.
    Pregnancy & lactationView
    The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.
    Pediatric usageView
    Use in children: The safety and effectiveness in pediatric patients have not been established.
    StorageView
    Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.

    Nestor

    Rosuvastatin
    Tablet 5 mg Allopathic Other Anti-anginal & Anti-ischaemic drugs

    Indications

    Stroke

    Indication detailsView
    Rosuvastatin is indicated in-
    • Heterozygous Hypercholesterolemia (Familial and Non familial)
    • Homozygous Hypercholesterolemia (Familial)
    • Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
    • Primary prevention of cardiovascular disease
    Therapeutic classView
    Other Anti-anginal & Anti-ischaemic drugs, Statins
    PharmacologyView
    Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.
    DosageView
    Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

    HoFH: Starting dose 20 mg/day.

    Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

    Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.
    AdministrationView
    Rosuvastatin can be taken with or without food, at any time of day.
    Side effectsView
    Rosuvastatin is generally well tolerated. The most frequent adverse events thought to be related to Rosuvastatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.
    ContraindicationsView
    Rosuvastatin is contraindicated if-
    • Known hypersensitivity to product components
    • Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
    • Pregnant women and women who may become pregnant
    • Nursing mothers
    PrecautionsView
    Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Rosuvastatin can be discontinued if signs or symptoms appear.

    Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur.

    Liver enzymes should be monitored before and during treatment
    InteractionsView
    Remarkable drug interactions of Rosuvastatin are-
    • Cyclosporine: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be limited to 5 mg once daily.
    • Gemfibrosil: Combination should be avoided. If used together, Rosuvastatin dose should be limited to 10 mg once daily.
    • Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be to 10 mg once daily.
    • Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rosuvastatin. INR should be monitored frequently until stable upon initiation or alteration of Rosuvastatin therapy.
    • Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.
    Pregnancy & lactationView
    The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.
    Pediatric usageView
    Use in children: The safety and effectiveness in pediatric patients have not been established.
    StorageView
    Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.

    Nesudil

    Netarsudil Dimesylate
    Ophthalmic Solution 0.02% Allopathic Drugs for miotics and glaucoma
    Indication detailsView
    Netarsudil ophthalmic solution is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
    Therapeutic classView
    Drugs for miotics and glaucoma
    PharmacologyView
    Netarsudil is a Rho kinase inhibitor, works at the cellular level within the trabecular outflow pathway to relax actin-myosin. This causes relaxation within the trabecular meshwork and the inner wall of Schlemm's canal and decreases episcleral venous pressure (EVP).
    DosageView
    The recommended dosage is one drop in the affected eye(s) once daily in the evening.
    Side effectsView
    The most common ocular adverse reaction observed in controlled clinical studies with Netarsudil was conjunctival hyperemia, corneal verticillata, instillation site pain, corneal staining and blurred vision.
    PrecautionsView
    For ophthalmic use only. To avoid possible contamination of the drops, do not touch the dropper tip or to any surface. Netarsudil can be used with other topical eye drug products, but they should be administered at least 5 minutes apart from each other. Contact lenses should be removed prior to instillation of Netarsudil and may be reinserted 15 minutes following its administration.
    InteractionsView
    This eye drops is contraindicated in patients who are hypersensitive to any component of this preparation.
    Pregnancy & lactationView
    Pregnancy: There are no adequate and well-controlled studies of Netarsudil ophthalmic solution in pregnant women to inform any drug-associated risk. However, systemic exposure to Netarsudil from ocular administration is low.

    Lactation: There are no data on the presence of Netarsudil in human milk, the effects on the breastfed infant, or the effects on milk production.

    Pediatric Use: Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

    Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients.
    StorageView
    Store at 2°-8°C in a dry place, protect from light until opened. After opening the product may be kept at 2°-25°C for upto 6 weeks. Keep out of the reach of children.

    Nesudil Plus

    Netarsudil + Latanoprost
    Ophthalmic Solution 0.02% + 0.005% Allopathic Drugs for miotics and glaucoma

    Indications

    Open angle glaucoma

    Indication detailsView
    This is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
    Therapeutic classView
    Drugs for miotics and glaucoma
    PharmacologyView
    This is a fixed-dose combination of a Rho kinase inhibitor and a Prostaglandin F2 analogue. Netarsudil is a Rho kinase inhibitor, works at the cellular level within the trabecular outflow pathway to relax actin-myosin. This causes relaxation within the trabecular meshwork and the inner wall of Schlemm's canal, and decrease episcleral venous pressure (EVP).

    Latanoprost is a selective FP receptor agonist which reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor through uveoscleral outflow.
    DosageView
    The recommended dosage is one drop in the affected eye(s) once daily in the evening.
    Side effectsView
    The most common ocular adverse reaction observed in controlled clinical studies with Netarsudil & Latanoprost was conjunctival hyperemia, instillation site pain, corneal verticillata, instillation site discomfort, foreign body sensation and blurred visions were reported in few patients.
    ContraindicationsView
    This eye drops is contraindicated in patients who are hypersensitive to any component of this preparation.
    PrecautionsView
    • For ophthalmic use only
    • To avoid possible contamination of the drops, do not touch the dropper tip or to any surface
    • Should be used with caution in patients with active intraocular inflammation (e.g., iritis/uveits)
    • May cause changes to pigmented tissues, gradually change eyelashes and vellus hair in the treated eye
    • Cystoid macular edema, has been reported during treatment with Latanoprost. Reactivation of Herpes Simplex keratitis may occur
    • Netarsudil & Latanoprost combination can be used with other topical eye drug products, but they should be administered at least 5 minutes apart from each other.
    Pregnancy & lactationView
    There are no adequate and well-controlled studies of Netarsudil & Latanoprost combination in pregnant women to inform any drug-associated risk. There are no data on the presence of Netarsudil or Latanoprost in human milk, the effects on the breastfed infant, or the effects on milk production.
    Pediatric usageView
    Pediatric Use: Safety and effectiveness in pediatric patients have not been established.

    Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients.
    StorageView
    Store at 2°-8°C in a dry place, protect from light until opened. After opening the product may be kept at 2°-25°C for upto 6 weeks. Keep out of the reach of children.

    Netac-R

    Ranitidine Hydrochloride
    Tablet 150 mg Allopathic H2 receptor antagonist

    Indications

    Zollinger-Ellison syndrome

    Indication detailsView
    Ranitidine is indicated in:
    • Treatment of active duodenal ulcer
    • Benign gastric ulcer
    • Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
    • Post operative stress ulcer.
    • Zollinger-Ellison Syndrome.
    • Gastroesophageal reflux disease (GERD).
    • Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient.
    • Recurrent haemorrhage in patients with bleeding peptic ulcer.
    • Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients.
    Therapeutic classView
    H2 receptor antagonist
    PharmacologyView
    Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
    DosageView

    Ranitidine Tablet & Syrup:

    Duodenal and gastric ulcer: The usual dosage is 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks.

    Reflux oesophagitis: 150 mg twice daily or 300 mg at bed time for up to 8 weeks.

    Zollinger Ellison syndrome: 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses. Dosage should be continued as long as clinically indicated.

    Episodic dyspepsia: 150 mg twice daily or 300 mg at bed time for up to 6 weeks.

    Maintenance: 150 mg at night for preventing recurrences.

    Child (peptic ulcer): 2-4 mg/kg twice daily, maximum 300 mg daily.


    Ranitidine IV injection & IV Infusion:

    Ranitidine injection may be given either as a slow (over a period of at least two minutes) intravenous injection of 50 mg, after dilution to a volume of 20 ml per 50 mg dose, which may be repeated every six to eight hours; or as an intermittent intravenous infusion at a rate of 25 mg per hour for two hours; the infusion may be repeated at six to eight hour intervals; or as an intramuscular injection of 50 mg (2 ml) every six to eight hours. In the prophylaxis of haemorrhage from stress ulceration in seriously ill patients or the prophylaxis of recurrent haemorrhage in patients bleeding from peptic ulceration, parenteral administration may be continued until oral feeding commences.

    In the prophylaxis of upper gastrointestinal haemorrhage from stress ulceration in seriously ill patient sapriming dose of 50 mg as low as intravenous injection followed by a continuous intravenous infusion of 0.125-0.250 mg/kg/hour may be preferred. In patients considered to be at risk of developing aspiration syndrome Ranitidine injection 50 mg may be given intramuscularly or by slow intravenous injection 45 to 60 minutes before induction of general anaesthesia.

    Children: The recommended oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day. Safety and effectiveness of Ranitidine injection have not been established in case of children.
    Side effectsView
    Ranitidine is well tolerated and side effects are usually uncommon. Altered bowel habit, dizziness, rash, tiredness, reversible confusional states, headache, decreased blood counts, muscle or joint pain have rarely been reported.
    ContraindicationsView
    Patients hypersensitive to Ranitidine
    PrecautionsView
    Ranitidine should be given in reduced dosage to patients with impaired renal and hepatic function.
    InteractionsView
    Delayed absorption and increased peak serum concentration with propantheline bromide. Ranitidine minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability with antacids.
    Pregnancy & lactationView
    Pregnancy: Ranitidine crosses the placenta. But there is no evidence of impaired fertility or harm to the foetus due to Ranitidine. Like other drugs, Ranitidine should only be used during pregnancy if considered essential.

    Lactation: Ranitidine is excreted in human breast milk. Caution should be exercised when the drug is administered to a nursing mother.
    Pediatric usageView
    Use in elderly patients: In clinical trial the ulcer healing rates have been found similar in patients age 65 and over with those in younger patients. Additionally, there was no difference in the incidence of adverse effects.
    Overdose effectsView
    Ranitidine is very specific in action and accordingly no particular problems are expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate. If required, the drug may be removed from the plasma by haemodiaiysis.
    ReconstitutionView
    Slow IV inj: Ranitidine 50 mg diluted to a concentration ≤2.5 mg/mL (e.g. total of 20 mL) with NaCl 0.9% inj or dextrose 5% or 10%, lactated Ringer's, Na bicarbonate 5% soln.

    Intermittent slow IV infusion: Ranitidine 50 mg diluted to a concentration ≤0.5 mg/mL (e.g. total of 100 mL) of dextrose 5% inj or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% soln.

    Continuous IV infusion:     Ranitidine 150 mg diluted in 250 mL of dextrose 5% inj or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% soln.

    Patients with Zollinger-Ellison syndrome or other hypersecretory conditions: Ranitidine should be diluted to a concentration ≤2.5 mg/mL with dextrose 5% or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% soln.
    StorageView
    Store in a cool and dry place. protect from light.