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    Amobin

    Metronidazole
    Tablet 200 mg Allopathic Amoebicides

    Indications

    Vaginal trichomoniasis

    Indication detailsView
    Metronidazole is indicated in the treatment of following diseases:
    • The prevention of post-operative infections due to anaerobic bacteria (particularly species of bacteroides and anaerobic streptococci).
    • The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis and post-operative wound infections caused by anaerobes.
    • In the treatment of urogenital trichomoniasis.
    • Bacterial vaginosis (also known as non-specific vaginitis).
    • All forms of amoebiasis (intestinal, extra-intestinal disease and that of symptomless cyst passers).
    • Giardiasis.
    • Acute ulcerative gingivitis.
    • Anaerobically infected leg ulcers and pressure sores.
    • Acute dental infections due to anaerobic organisms.
    • Antibiotic associated pseudomembranus colitis.
    Therapeutic classView
    Amoebicides, Anti-diarrhoeal Antiprotozoal
    PharmacologyView
    Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.
    DosageView

    Tablet and Suspension:

    Trichomoniasis (Adults & Children over 10 yrs)-
    • 200 mg tid or 400 mg bid for 7 days
    • 800 mg in the morning and 1-2 gm at night for 2 days
    • 2 gm as a single dose for 1 days
    Trichomoniasis (Children)-
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
    Intestinal amoebiasis (Adults & Children over 10 yrs)- 
    • 800 mg tid for 5 days
    Intestinal amoebiasis (Children)-
    • Children 7-10 yrs: 400 mg tid
    • Children 3-7 yrs: 200 mg qid
    • Children 1-3 yrs: 200 mg tid
    Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-
    • 400-800 mg tid for 5-10 days
    Extra-intestinal & Asymptomatic amoebiasis (Children)-
    • Children 7-10 yrs: 200-400 mg tid
    • Children 3-7 yrs: 100-200 mg qid
    • Children 1-3 yrs: 100-200 mg tid
    Giardiasis (Adults & Children over 10 yrs)-
    • 2 gm once daily for 3 days
    Giardiasis (Children)-
    • Children 7-10 yrs: 1 gm once daily
    • Children 3-7 yrs: 600-800 mg once daily
    • Children 1-3 yrs: 500 mg once daily
    Acute ulcerative  gingivitis (Adults & Children over 10 yrs)-
    • 200 mg tid for 3 days
    Acute ulcerative  gingivitis (Children)-
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
    Acute dental infections (Adults & Children over 10 yrs)-
    • 200 mg tid for 3-7 days
    Bacterial Vaginosis (Adults & Children over 10 yrs)-
    • 400 mg bid for 7 days
    • 2 gm as a single dose for 1 days
    Leg ulcers and pressure sores (Adults & Children over 10 yrs)-
    • 400 mg tid for 7 days
    Anaerobic infections (Adults & Children over 10 yrs)-
    • 800 mg initially and then 400 mg tid for 7 days
    Anaerobic infections (Children)-
    • Children 1-10 yrs: 7.5 mg/kg tid
    Surgical prophylaxis (Adults & Children over 10 yrs)-
    • 400 mg tid started 24  hours before  surgery for 1 days
    Surgical prophylaxis (Children)-
    • Children 1-10 yrs: 7.5 mg/kg tid

    Vaginal Gel:

    The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, Metronidazole gel should be administered at bedtime.


    Suppository:

    Anaerobic Infections-
    • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours.
    • Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.
    Surgical Prophylaxis-
    • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.
    • Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.


    IV Infusion:

    Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.
    • Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended, especially for cases where reinfection is likely. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.
    • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute.
    Side effectsView
    Metallic taste, nausea, vomiting, diarrhoea, drowsiness, rashes may be observed during treatment.
    ContraindicationsView
    Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
    PrecautionsView
    • If for compelling reasons, metronidazole must be administered longer than the usually recommended duration, it is recommended that hematological tests, especially leucocyte count should be carried out regularly and that patients should be monitored for adverse reactions such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).
    • Metronidazole should be administered with caution to patients with hepatic encephalopathy.
    • Patients should be warned that metronidazole may darken urine.
    InteractionsView
    • Disulfiram: Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.
    • Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards because of the possibility of a disulfiram-like (antabuse effect) reaction (flushing, vomiting, tachycardia). Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In case of co-administration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole.
    • Lithium: Plasma levels of lithium may be increased by metronidazole.
    • Cyclosporin: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.
    • Phenytoin or phenobarbital: increased elimination of metronidazole resulting in reduced plasma levels.
    • 5-Fluorouracil: Reduced clearance of 5-fluorouracil resulting in increased toxicity of 5-fluorouracil.
    • Busulfan: Plasma levels of busulfan may be increased by metronidazole, which may lead to severe busulfan toxicity.
    Pregnancy & lactationView
    US FDA Pregnancy Category of Metronidazole is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Metronidazole have been shown to be excreted in human milk. So, caution should be exercised when Metronidazole is administered to a nursing woman.
    Pediatric usageView
    Hepatic impairment: Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of metronidazole clearance may occur in the presence of advanced hepatic insufficiency. Significant cumulation may occur in patients with hepatic encephalopathy and the resulting high plasma concentrations of metronidazole may contribute to the symptoms of the encephalopathy. Metronidazole should therefore, be administered with caution to patients with hepatic encephalopathy. The daily dosage should be reduced to one third and may be administered once daily. Patients should be warned that metronidazole may darken urine.

    Renal impairment: The elimination half-life of metronidazole remains unchanged in the presence of renal failure. The dosage of metronidazole therefore needs no reduction. Such patients however retain the metabolites of metronidazole. The clinical significance of this is not known at present. In patients undergoing haemodialysis metronidazole and metabolites are efficiently removed during an eight hour period of dialysis. Metronidazole should therefore be re-administered immediately after haemodialysis. No routine adjustment in the dosage of Metronidazole need be made in patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD).
    Overdose effectsView
    Single oral doses of metronidazole, up to 12 g have been reported in suicide attempts and accidental overdoses. Symptoms were limited to vomiting, ataxia and slight disorientation. There is no specific antidote for metronidazole overdosages. In case of suspected massive overdosages, a symptomatic and supportive treatment should be instituted.
    StorageView
    Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.

    Amobin

    Metronidazole
    Oral Suspension 200 mg/5 ml Allopathic Amoebicides

    Indications

    Vaginal trichomoniasis

    Indication detailsView
    Metronidazole is indicated in the treatment of following diseases:
    • The prevention of post-operative infections due to anaerobic bacteria (particularly species of bacteroides and anaerobic streptococci).
    • The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis and post-operative wound infections caused by anaerobes.
    • In the treatment of urogenital trichomoniasis.
    • Bacterial vaginosis (also known as non-specific vaginitis).
    • All forms of amoebiasis (intestinal, extra-intestinal disease and that of symptomless cyst passers).
    • Giardiasis.
    • Acute ulcerative gingivitis.
    • Anaerobically infected leg ulcers and pressure sores.
    • Acute dental infections due to anaerobic organisms.
    • Antibiotic associated pseudomembranus colitis.
    Therapeutic classView
    Amoebicides, Anti-diarrhoeal Antiprotozoal
    PharmacologyView
    Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.
    DosageView

    Tablet and Suspension:

    Trichomoniasis (Adults & Children over 10 yrs)-
    • 200 mg tid or 400 mg bid for 7 days
    • 800 mg in the morning and 1-2 gm at night for 2 days
    • 2 gm as a single dose for 1 days
    Trichomoniasis (Children)-
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
    Intestinal amoebiasis (Adults & Children over 10 yrs)- 
    • 800 mg tid for 5 days
    Intestinal amoebiasis (Children)-
    • Children 7-10 yrs: 400 mg tid
    • Children 3-7 yrs: 200 mg qid
    • Children 1-3 yrs: 200 mg tid
    Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-
    • 400-800 mg tid for 5-10 days
    Extra-intestinal & Asymptomatic amoebiasis (Children)-
    • Children 7-10 yrs: 200-400 mg tid
    • Children 3-7 yrs: 100-200 mg qid
    • Children 1-3 yrs: 100-200 mg tid
    Giardiasis (Adults & Children over 10 yrs)-
    • 2 gm once daily for 3 days
    Giardiasis (Children)-
    • Children 7-10 yrs: 1 gm once daily
    • Children 3-7 yrs: 600-800 mg once daily
    • Children 1-3 yrs: 500 mg once daily
    Acute ulcerative  gingivitis (Adults & Children over 10 yrs)-
    • 200 mg tid for 3 days
    Acute ulcerative  gingivitis (Children)-
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
    Acute dental infections (Adults & Children over 10 yrs)-
    • 200 mg tid for 3-7 days
    Bacterial Vaginosis (Adults & Children over 10 yrs)-
    • 400 mg bid for 7 days
    • 2 gm as a single dose for 1 days
    Leg ulcers and pressure sores (Adults & Children over 10 yrs)-
    • 400 mg tid for 7 days
    Anaerobic infections (Adults & Children over 10 yrs)-
    • 800 mg initially and then 400 mg tid for 7 days
    Anaerobic infections (Children)-
    • Children 1-10 yrs: 7.5 mg/kg tid
    Surgical prophylaxis (Adults & Children over 10 yrs)-
    • 400 mg tid started 24  hours before  surgery for 1 days
    Surgical prophylaxis (Children)-
    • Children 1-10 yrs: 7.5 mg/kg tid

    Vaginal Gel:

    The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, Metronidazole gel should be administered at bedtime.


    Suppository:

    Anaerobic Infections-
    • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours.
    • Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.
    Surgical Prophylaxis-
    • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.
    • Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.


    IV Infusion:

    Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.
    • Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended, especially for cases where reinfection is likely. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.
    • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute.
    Side effectsView
    Metallic taste, nausea, vomiting, diarrhoea, drowsiness, rashes may be observed during treatment.
    ContraindicationsView
    Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
    PrecautionsView
    • If for compelling reasons, metronidazole must be administered longer than the usually recommended duration, it is recommended that hematological tests, especially leucocyte count should be carried out regularly and that patients should be monitored for adverse reactions such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).
    • Metronidazole should be administered with caution to patients with hepatic encephalopathy.
    • Patients should be warned that metronidazole may darken urine.
    InteractionsView
    • Disulfiram: Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.
    • Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards because of the possibility of a disulfiram-like (antabuse effect) reaction (flushing, vomiting, tachycardia). Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In case of co-administration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole.
    • Lithium: Plasma levels of lithium may be increased by metronidazole.
    • Cyclosporin: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.
    • Phenytoin or phenobarbital: increased elimination of metronidazole resulting in reduced plasma levels.
    • 5-Fluorouracil: Reduced clearance of 5-fluorouracil resulting in increased toxicity of 5-fluorouracil.
    • Busulfan: Plasma levels of busulfan may be increased by metronidazole, which may lead to severe busulfan toxicity.
    Pregnancy & lactationView
    US FDA Pregnancy Category of Metronidazole is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Metronidazole have been shown to be excreted in human milk. So, caution should be exercised when Metronidazole is administered to a nursing woman.
    Pediatric usageView
    Hepatic impairment: Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of metronidazole clearance may occur in the presence of advanced hepatic insufficiency. Significant cumulation may occur in patients with hepatic encephalopathy and the resulting high plasma concentrations of metronidazole may contribute to the symptoms of the encephalopathy. Metronidazole should therefore, be administered with caution to patients with hepatic encephalopathy. The daily dosage should be reduced to one third and may be administered once daily. Patients should be warned that metronidazole may darken urine.

    Renal impairment: The elimination half-life of metronidazole remains unchanged in the presence of renal failure. The dosage of metronidazole therefore needs no reduction. Such patients however retain the metabolites of metronidazole. The clinical significance of this is not known at present. In patients undergoing haemodialysis metronidazole and metabolites are efficiently removed during an eight hour period of dialysis. Metronidazole should therefore be re-administered immediately after haemodialysis. No routine adjustment in the dosage of Metronidazole need be made in patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD).
    Overdose effectsView
    Single oral doses of metronidazole, up to 12 g have been reported in suicide attempts and accidental overdoses. Symptoms were limited to vomiting, ataxia and slight disorientation. There is no specific antidote for metronidazole overdosages. In case of suspected massive overdosages, a symptomatic and supportive treatment should be instituted.
    StorageView
    Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.

    Amobin

    Metronidazole
    Tablet 400 mg Allopathic Amoebicides

    Indications

    Vaginal trichomoniasis

    Indication detailsView
    Metronidazole is indicated in the treatment of following diseases:
    • The prevention of post-operative infections due to anaerobic bacteria (particularly species of bacteroides and anaerobic streptococci).
    • The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis and post-operative wound infections caused by anaerobes.
    • In the treatment of urogenital trichomoniasis.
    • Bacterial vaginosis (also known as non-specific vaginitis).
    • All forms of amoebiasis (intestinal, extra-intestinal disease and that of symptomless cyst passers).
    • Giardiasis.
    • Acute ulcerative gingivitis.
    • Anaerobically infected leg ulcers and pressure sores.
    • Acute dental infections due to anaerobic organisms.
    • Antibiotic associated pseudomembranus colitis.
    Therapeutic classView
    Amoebicides, Anti-diarrhoeal Antiprotozoal
    PharmacologyView
    Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.
    DosageView

    Tablet and Suspension:

    Trichomoniasis (Adults & Children over 10 yrs)-
    • 200 mg tid or 400 mg bid for 7 days
    • 800 mg in the morning and 1-2 gm at night for 2 days
    • 2 gm as a single dose for 1 days
    Trichomoniasis (Children)-
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
    Intestinal amoebiasis (Adults & Children over 10 yrs)- 
    • 800 mg tid for 5 days
    Intestinal amoebiasis (Children)-
    • Children 7-10 yrs: 400 mg tid
    • Children 3-7 yrs: 200 mg qid
    • Children 1-3 yrs: 200 mg tid
    Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-
    • 400-800 mg tid for 5-10 days
    Extra-intestinal & Asymptomatic amoebiasis (Children)-
    • Children 7-10 yrs: 200-400 mg tid
    • Children 3-7 yrs: 100-200 mg qid
    • Children 1-3 yrs: 100-200 mg tid
    Giardiasis (Adults & Children over 10 yrs)-
    • 2 gm once daily for 3 days
    Giardiasis (Children)-
    • Children 7-10 yrs: 1 gm once daily
    • Children 3-7 yrs: 600-800 mg once daily
    • Children 1-3 yrs: 500 mg once daily
    Acute ulcerative  gingivitis (Adults & Children over 10 yrs)-
    • 200 mg tid for 3 days
    Acute ulcerative  gingivitis (Children)-
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
    Acute dental infections (Adults & Children over 10 yrs)-
    • 200 mg tid for 3-7 days
    Bacterial Vaginosis (Adults & Children over 10 yrs)-
    • 400 mg bid for 7 days
    • 2 gm as a single dose for 1 days
    Leg ulcers and pressure sores (Adults & Children over 10 yrs)-
    • 400 mg tid for 7 days
    Anaerobic infections (Adults & Children over 10 yrs)-
    • 800 mg initially and then 400 mg tid for 7 days
    Anaerobic infections (Children)-
    • Children 1-10 yrs: 7.5 mg/kg tid
    Surgical prophylaxis (Adults & Children over 10 yrs)-
    • 400 mg tid started 24  hours before  surgery for 1 days
    Surgical prophylaxis (Children)-
    • Children 1-10 yrs: 7.5 mg/kg tid

    Vaginal Gel:

    The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, Metronidazole gel should be administered at bedtime.


    Suppository:

    Anaerobic Infections-
    • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours.
    • Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.
    Surgical Prophylaxis-
    • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.
    • Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.


    IV Infusion:

    Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.
    • Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended, especially for cases where reinfection is likely. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.
    • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute.
    Side effectsView
    Metallic taste, nausea, vomiting, diarrhoea, drowsiness, rashes may be observed during treatment.
    ContraindicationsView
    Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
    PrecautionsView
    • If for compelling reasons, metronidazole must be administered longer than the usually recommended duration, it is recommended that hematological tests, especially leucocyte count should be carried out regularly and that patients should be monitored for adverse reactions such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).
    • Metronidazole should be administered with caution to patients with hepatic encephalopathy.
    • Patients should be warned that metronidazole may darken urine.
    InteractionsView
    • Disulfiram: Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.
    • Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards because of the possibility of a disulfiram-like (antabuse effect) reaction (flushing, vomiting, tachycardia). Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In case of co-administration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole.
    • Lithium: Plasma levels of lithium may be increased by metronidazole.
    • Cyclosporin: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.
    • Phenytoin or phenobarbital: increased elimination of metronidazole resulting in reduced plasma levels.
    • 5-Fluorouracil: Reduced clearance of 5-fluorouracil resulting in increased toxicity of 5-fluorouracil.
    • Busulfan: Plasma levels of busulfan may be increased by metronidazole, which may lead to severe busulfan toxicity.
    Pregnancy & lactationView
    US FDA Pregnancy Category of Metronidazole is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Metronidazole have been shown to be excreted in human milk. So, caution should be exercised when Metronidazole is administered to a nursing woman.
    Pediatric usageView
    Hepatic impairment: Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of metronidazole clearance may occur in the presence of advanced hepatic insufficiency. Significant cumulation may occur in patients with hepatic encephalopathy and the resulting high plasma concentrations of metronidazole may contribute to the symptoms of the encephalopathy. Metronidazole should therefore, be administered with caution to patients with hepatic encephalopathy. The daily dosage should be reduced to one third and may be administered once daily. Patients should be warned that metronidazole may darken urine.

    Renal impairment: The elimination half-life of metronidazole remains unchanged in the presence of renal failure. The dosage of metronidazole therefore needs no reduction. Such patients however retain the metabolites of metronidazole. The clinical significance of this is not known at present. In patients undergoing haemodialysis metronidazole and metabolites are efficiently removed during an eight hour period of dialysis. Metronidazole should therefore be re-administered immediately after haemodialysis. No routine adjustment in the dosage of Metronidazole need be made in patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD).
    Overdose effectsView
    Single oral doses of metronidazole, up to 12 g have been reported in suicide attempts and accidental overdoses. Symptoms were limited to vomiting, ataxia and slight disorientation. There is no specific antidote for metronidazole overdosages. In case of suspected massive overdosages, a symptomatic and supportive treatment should be instituted.
    StorageView
    Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.

    Amocal

    Amlodipine Besilate
    Tablet 5 mg Allopathic Calcium-channel blockers

    Indications

    Stroke

    Indication detailsView
    Essential hypertension: Amlodipine is efficacious as monotherapy in the treatment of hypertension. It may be used in combination with other antihypertensive agents.

    Angina pectoris: Amlodipine is indicated for the treatment of chronic stable angina pectoris and is efficacious as monotherapy. It may be used in combination with other antianginal agents.

    Vasospastic angina: Amlodipine is indicated for the treatment of confirmed or suspected vasospastic angina. It may be used as monotherapy or in combination with other antianginal drugs.
    Therapeutic classView
    Calcium-channel blockers
    PharmacologyView
    Amlodipine is a dihydropyridine calcium-channel blocker, with a long duration of action, used for the treatment of hypertension and angina pectoris. Amlodipine influences the myocardial cells, the cells within the specialized conducting system of the heart, and the cells of vascular smooth muscle. Administration of Amlodipine results primarily in vasodilation, with reduced peripheral resistance, blood pressure and afterload, increased coronary blood flow and a reflex increase in coronary heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.
    DosageView
    Hypertension: Usual dose is 5 mg once daily. The maximum dose is 10 mg once daily. Elderly patients with hepatic insufficiency may be started on 2.5 mg once daily; this dose may also be used when adding Amlodipine to other antihypertensive therapy.

    Angina (Chronic stable or Vasospastic): 5 to 10 mg, using the lower dose for elderly and in patients with hepatic insufficiency. Most patients require 10 mg.

    Administrations: May be taken without regard to meals.
    Side effectsView
    The most common adverse effects of amlodipine are associated with vasodilatory action, such as dizziness, flushing, headache, hypotension and peripheral edema. Gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain and mental depression may also occur. A paradoxical increase in ischaemic chest pain may occur at the start of the treatment and in a few patients excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness. Rashes, fever and abnormalities in liver function due to hypersensitivity reaction of Amlodipine may occur.
    ContraindicationsView
    Hypersensitivity to dihydropyridine derivatives. Pregnant woman.
    PrecautionsView
    Precaution should be taken in patients with hepatic impairment and during pregnancy and breast feeding.
    InteractionsView
    Drug Interactions-
    • Potentially hazardous interactions: Little or no data are available in patients with markedly impaired cardiac left ventricular function; however, as with other calcium antagonist drugs, the combination of Amlodipine and p-blockers should be avoided in such patients.
    Other Significant Interactions-
    • Digoxin: Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been documented in a controlled clinical study.
    • Cimetidine: An unpublished clinical study indicated no interaction between, Amlodipine and Cimetidine in healthy volunteers.
    • Warfarin: An unpublished clinical study in healthy volunteers indicates that Amlodipine did not significantly alter the effect of Warfarin on prothrombin time.
    • Food: Food does not alter the rate or extent of absorption of Amlodipine.
    Pregnancy & lactationView
    Pregnancy Category C. There are no adequate and well-controlled studies of Amlodipine in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Amlodipine is excreted in human milk. In the absence of this information, it is recommended that nursing be discontinued while Amlodipine is administered.
    Pediatric usageView
    Children with hypertension from 6 years to 17 years of age: 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in pediatric patients.

    Children under 6 years old:  The effect of amlodipine on blood pressure in patients less than 6 years of age is not known.

    Elderly: Amlodipine used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care.

    Renal impairment: Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Amlodipine is not dialysable.

    Hepatic impairment: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore dose selection should be cautions and should start at the lower end of the dosing range. The pharmacokinetics of Amlodipine have not been studied in severe hepatic impairment. Amlodipine should be initiated at the lowest dose (2.5 mg once daily) and titrated slowly in patients with severe hepatic impairment.
    Overdose effectsView
    Symptoms: Available data suggest that large overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to and including shock with fatal outcome have been reported.

    Management: Clinically significant hypotension due to amlodipine overdosage calls for active cardiovascular support including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulating fluid volume and urine output. 

    A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade. Gastric lavage may be worthwhile in some cases. In healthy volunteers the use of charcoal up to 2 hours after administration of amlodipine 10 mg has been shown to reduce the absorption rate of amlodipine. Since amlodipine is highly protein-bound, dialysis is not likely to be of benefit.
    StorageView
    Keep all medicines out of reach of children. Store in a cool & dry place, protected from light.

    Amocal

    Amlodipine Besilate
    Tablet 10 mg Allopathic Calcium-channel blockers

    Indications

    Stroke

    Indication detailsView
    Essential hypertension: Amlodipine is efficacious as monotherapy in the treatment of hypertension. It may be used in combination with other antihypertensive agents.

    Angina pectoris: Amlodipine is indicated for the treatment of chronic stable angina pectoris and is efficacious as monotherapy. It may be used in combination with other antianginal agents.

    Vasospastic angina: Amlodipine is indicated for the treatment of confirmed or suspected vasospastic angina. It may be used as monotherapy or in combination with other antianginal drugs.
    Therapeutic classView
    Calcium-channel blockers
    PharmacologyView
    Amlodipine is a dihydropyridine calcium-channel blocker, with a long duration of action, used for the treatment of hypertension and angina pectoris. Amlodipine influences the myocardial cells, the cells within the specialized conducting system of the heart, and the cells of vascular smooth muscle. Administration of Amlodipine results primarily in vasodilation, with reduced peripheral resistance, blood pressure and afterload, increased coronary blood flow and a reflex increase in coronary heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.
    DosageView
    Hypertension: Usual dose is 5 mg once daily. The maximum dose is 10 mg once daily. Elderly patients with hepatic insufficiency may be started on 2.5 mg once daily; this dose may also be used when adding Amlodipine to other antihypertensive therapy.

    Angina (Chronic stable or Vasospastic): 5 to 10 mg, using the lower dose for elderly and in patients with hepatic insufficiency. Most patients require 10 mg.

    Administrations: May be taken without regard to meals.
    Side effectsView
    The most common adverse effects of amlodipine are associated with vasodilatory action, such as dizziness, flushing, headache, hypotension and peripheral edema. Gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain and mental depression may also occur. A paradoxical increase in ischaemic chest pain may occur at the start of the treatment and in a few patients excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness. Rashes, fever and abnormalities in liver function due to hypersensitivity reaction of Amlodipine may occur.
    ContraindicationsView
    Hypersensitivity to dihydropyridine derivatives. Pregnant woman.
    PrecautionsView
    Precaution should be taken in patients with hepatic impairment and during pregnancy and breast feeding.
    InteractionsView
    Drug Interactions-
    • Potentially hazardous interactions: Little or no data are available in patients with markedly impaired cardiac left ventricular function; however, as with other calcium antagonist drugs, the combination of Amlodipine and p-blockers should be avoided in such patients.
    Other Significant Interactions-
    • Digoxin: Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been documented in a controlled clinical study.
    • Cimetidine: An unpublished clinical study indicated no interaction between, Amlodipine and Cimetidine in healthy volunteers.
    • Warfarin: An unpublished clinical study in healthy volunteers indicates that Amlodipine did not significantly alter the effect of Warfarin on prothrombin time.
    • Food: Food does not alter the rate or extent of absorption of Amlodipine.
    Pregnancy & lactationView
    Pregnancy Category C. There are no adequate and well-controlled studies of Amlodipine in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Amlodipine is excreted in human milk. In the absence of this information, it is recommended that nursing be discontinued while Amlodipine is administered.
    Pediatric usageView
    Children with hypertension from 6 years to 17 years of age: 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in pediatric patients.

    Children under 6 years old:  The effect of amlodipine on blood pressure in patients less than 6 years of age is not known.

    Elderly: Amlodipine used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care.

    Renal impairment: Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Amlodipine is not dialysable.

    Hepatic impairment: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore dose selection should be cautions and should start at the lower end of the dosing range. The pharmacokinetics of Amlodipine have not been studied in severe hepatic impairment. Amlodipine should be initiated at the lowest dose (2.5 mg once daily) and titrated slowly in patients with severe hepatic impairment.
    Overdose effectsView
    Symptoms: Available data suggest that large overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to and including shock with fatal outcome have been reported.

    Management: Clinically significant hypotension due to amlodipine overdosage calls for active cardiovascular support including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulating fluid volume and urine output. 

    A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade. Gastric lavage may be worthwhile in some cases. In healthy volunteers the use of charcoal up to 2 hours after administration of amlodipine 10 mg has been shown to reduce the absorption rate of amlodipine. Since amlodipine is highly protein-bound, dialysis is not likely to be of benefit.
    StorageView
    Keep all medicines out of reach of children. Store in a cool & dry place, protected from light.

    Amocal-AT

    Amlodipine Besilate + Atenolol
    Tablet 5 mg+50 mg Allopathic Combined antihypertensive preparations

    Indications

    Refractory angina pectoris where nitrate therapy has failed

    Indication detailsView
    This is indicated in-
    • Patients with essential hypertension
    • Patients with angina pectoris & hypertension as co-existing diseases
    • ln post Ml patients
    • ln patients with refractory angina pectoris where nitrate therapy has failed.
    Therapeutic classView
    Combined antihypertensive preparations
    PharmacologyView
    This is a fixed-dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular smooth muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload.

    Atenolol is a cardioselective beta-blocker. The cardio-selectivity is dose-related. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.
    DosageView
    The recommended dosage is Amlodipine and Atenolol 5/25 mg tablet once daily. If necessary, the dosage may be increased to 5/25 mg two tablets daily or as advised by the physicians. The dosage however should be individualized.
    Side effectsView
    The combination of Amlodipine and Atenolol is well tolerated. Overall side-effects include
    fatigue, headache, edema, nausea, drowsiness, anxiety and depression.
    ContraindicationsView
    Hypersensitivity to either component, sinus bradycardia, second and higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function.
    PrecautionsView
    Bronchospasm: The combination should be used with caution in patients with airway obstruction.

    Renal impairment: The combination can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30 ml/min because of possible reduction in the excretion of unchanged Atenolol.

    Hepatic impairment: Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half-life of Amlodipine.

    Drug withdrawal: Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly. Any discontinuation should be gradual and under observation.
    InteractionsView
    Disopyramide: Atenolol reduces the clearance of disopyramide by 20%. Additive negative inotropic effects on the heart may be produced.

    Ampicillin: at doses of 1 gm and above may reduce Atenolol levels.

    Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion e.g. in response to oral antidiabetics. Atenolol has less potential for these actions.
    Pregnancy & lactationView
    The combination should be used during pregnancy only if the expected benefit outweighs the potential fetal risk. The combination should not be used by nursing mothers. If its use is considered necessary, breast-feeding should be stopped.
    Overdose effectsView
    Though not documented, hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested.
    StorageView
    Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

    Amocal-BZ

    Amlodipine Besilate + Benazepril Hydrochloride
    Capsule 5 mg+10 mg Allopathic Combined antihypertensive preparations

    Indications

    Hypertension

    Indication detailsView
    This combination is indicated for the treatment of hypertension. This fixed combination drug is not indicated for the initial therapy of hypertension.
    Therapeutic classView
    Combined antihypertensive preparations
    PharmacologyView
    The combination of Amlodipine and Benazepril is used to treat high blood pressure. Benazepril and benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and in animals. While the mechanism through which Benazepril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin aldosterone system, Benazepril has an antihypertensive effect even in patients with low-renin hypertension. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

    The rate and extent of absorption of Benazepril and Amlodipine are not significantly different, respectively, from the rate and extent of absorption of Benazepril and Amlodipine from individual tablet formulations. Following oral administration of this capsule, peak plasma concentrations of Benazepril are reached in 0.5-2 hours. Peak plasma concentrations of Amlodipine are reached 6-12 hours after administration of this capsule; the extent of absorption is 64%-90%. Over 700 patients received Benazepril/Amlodipine once daily in five double-blind, placebo-controlled studies. Benazepril/Amlodipine lowered blood pressure within 1 hour, with peak reductions achieved 2-8 hours after dosing. The antihypertensive effect of a single dose persisted for 24 hours. Once-daily doses of Benazepril/Amlodipine using Benazepril doses of 10-20 mg and Amlodipine doses of 2.5-10 mg decreased seated pressure (systolic/diastolic) 24 hours after dosing by about 10-25/6-13 mmHg.
    DosageView
    Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while Benazepril is effective in doses of 10-80 mg.

    It is usually appropriate to begin therapy with this capsule only after a patient has either-
    • Failed to achieve the desired antihypertensive effect with one or the other monotherapy, or
    • Demonstrated inability to achieve adequate antihypertensive effect with Amlodipine therapy without developing edema.
    Dose Titration Guided by Clinical Effect: A patient whose blood pressure is not adequately controlled with Amlodipine (or another dihydropyridine) alone or with Benazepril (or another ACE inhibitor) alone may be switched to combination therapy with this capsule. All patient groups benefit from the reduction in Amlodipine-induced edema. Dosage must be guided by clinical response; steady-state levels of Benazepril an Amlodipine will be reached after approximately 2 and 7 days of dosing respectively.

    In patients whose blood pressures are adequately controlled with Amlodipine but who experience unacceptable edema, combination therapy may achieve similar (or better) blood-pressure control without edema. Especially in nonblacks, it may be prudent to minimize the risk of excessive response by reducing the dose of Amlodipine as Benazepril is added to the regimen.

    Replacement Therapy: For convenience, patients receiving Amlodipine and Benazepril from separate tablets may instead wish to receive this capsule containing the same component doses. In small, elderly, or hepatically impaired patients, the recommended initial dose of Amlodipine, as monotherapy or as a component of combination therapy, is 2.5 mg.
    Side effectsView
    Benazepril/Amlodipine has been evaluated for safety in patients with hypertension for at least 6 months and more than 1 year. The reported side effects were generally mild and transient, and there was no relationship between side effects and age, sex, race or duration of therapy. Discontinuation of therapy due to side effects was required in approximately 4% of patients treated with Benazepril/Amlodipine and in 3% of patients treated with placebo. The most common reasons for discontinuation of therapy with Benazepril/Amlodipine in U.S. studies were cough and edema. The side effects considered possibly or probably related to study drug that occurred in U.S. placebo-controlled trials in more than 1% of patients treated with Benazepril/Amlodipine are cough, headache, dizziness and edema.

    The incidence of edema was statistically greater in patients treated with Amlodipine monotherapy than in patients treated with the combination. Edema and certain other side effects are associated with Amlodipine monotherapy in a dose-dependent manner, and appear to affect women more than men. The addition of Benazepril resulted in lower incidences as shown in study; the protective effect of Benazepril was independent of race and (within the range of doses tested) of dose.

    Other rare side effects are angioedema, asthenia, fatigue, insomnia, nervousness, anxiety, tremor, decreased libido, flushing, hot flashes, rash, skin nodule, dermatitis, dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis, hypokalemia, pharyngitis etc.
    ContraindicationsView
    This capsule is contraindicated in patients who are hypersensitive to Benazepril, to any other ACE inhibitor, or to Amlodipine.
    PrecautionsView
    Impaired Renal Function: This capsule should be used with caution in patients with severe renal disease.

    Hyperkalemia: This may occur in only a few patients but generally are reversible.

    Patients With Hepatic Failure: Since Amlodipine is extensively metabolized by the liver and the plasma elimination half-life (t ½) is 56 hours in patients with impaired hepatic function, caution should be exercised when administering this capsule to patients with severe hepatic impairment.

    Cough: ACE inhibitor-induced cough should be considered in the differential diagnosis of cough.

    Surgery/Anesthesia: In patients undergoing surgery or during anesthesia with agents that produce hypotension, Benazepril will block the angiotensin II formation that could otherwise occur secondary to compensatory renin release. Hypotension that occurs as a result of this mechanism can be corrected by volume expansion.

    Carcinogenesis, Mutagenesis, Impairment of Fertility: No evidence of carcinogenicity, mutagenicity or impairment of fertility was found when the Benazepril/Amlodipine combination were given orally.
    InteractionsView
    Diuretics: Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Benazepril/Amlodipine.

    Potassium Supplements and Potassium-Sparing Diuretics: Benazepril can attenuate potassium loss caused by thiazide diuretics. Potassium-sparing diuretics (Spironolactone, Amiloride, Triamterene and others) or potassium supplements can increase the risk of hyperkalemia. If concomitant use of such agents is indicated, they should be given with caution, and the patient's serum potassium should be monitored frequently.

    Others: Benazepril has been used concomitantly with oral anticoagulants, beta-adrenergic-blocking agents, calcium-blocking agents, Cimetidine, diuretics, Digoxin, Hydralazine, and Naproxen without evidence of clinically important adverse interactions.

    In clinical trials, Amlodipine has been safely administered with thiazide diuretics, beta blockers, ACE inhibitors, long-acting nitrates, sublingual nitroglycerin, Digoxin, Warfarin, nonsteroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs.
    Pregnancy & lactationView
    Pregnancy Categories C (first trimester) and D (second and third trimesters). ACE inhibitors can cause fetal and neonatal morbidity and death when administered to pregnant women. Several dozen cases have been reported in the world literature. When pregnancy is detected, this capsule should be discontinued as soon as possible. Minimal amounts of unchanged Benazepril and of benazeprilat are excreted into the breast milk of lactating women treated with Benazepril, so that a newborn child ingesting nothing but breast milk would receive less than 0.1% of the maternal doses of Benazepril and benazeprilat. It is not known whether Amlodipine is excreted in human milk. In the absence of this information, it is recommended that nursing be discontinued while this capsule is administered.
    Pediatric usageView
    Geriatric Use: Clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

    Pediatric Use: Safety and effectiveness in pediatric patients have not been established.
    Overdose effectsView
    Human overdoses with any combination of Amlodipine and Benazepril have not been reported. In scattered reports of human overdoses with Benazepril and other ACE inhibitors, there are no reports of death.
    StorageView
    Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.

    Amocap

    Amoxicillin Trihydrate
    Capsule 500 mg Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocap

    Amoxicillin Trihydrate
    Capsule 250 mg Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocil

    Amoxicillin Trihydrate
    Capsule 250 mg Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocil

    Amoxicillin Trihydrate
    Powder for Suspension 125 mg/5 ml Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocil

    Amoxicillin Trihydrate
    Capsule 500 mg Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocin

    Amoxicillin Trihydrate
    Capsule 250 mg Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocin

    Amoxicillin Trihydrate
    Powder for Suspension 125 mg/5 ml Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amocin

    Amoxicillin Trihydrate
    Capsule 500 mg Allopathic Broad spectrum penicillins

    Indications

    Skin and skin sructure infections

    Indication detailsView
    Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
    • Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
    • Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
    • Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculosis, infected wounds, abscess)
    • Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
    • Venereal disease (i.e. acute uncomplicated gonorrhoea)
    • In dental abscess, it is used as short-term therapy.
    • It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
    DosageView
    Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

    Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
    • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
    • Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
    • Pneumonia: Recommended dose is 500-1000 mg three times daily.
    • Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
    • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
    • In renal impairment: it may be necessary to reduce the total daily dosage.
    AdministrationView
    Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately.
    Side effectsView
    Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
    ContraindicationsView
    Amoxicillin is contraindicated in penicillin hypersensitive patients.
    PrecautionsView
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
    InteractionsView
    Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
    Pregnancy & lactationView
    US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
    ReconstitutionView
    Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
    • Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
    StorageView
    Keep in a dry place away from light and heat. Keep out of the reach of children.

    Amoclav

    Amoxicillin + Clavulanic Acid
    IV Injection (1 gm+200 mg)/20 ml Allopathic Broad spectrum penicillins

    Indications

    Severe or recurrent respiratory tract infections

    Indication detailsView
    Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites:
    • Upper respiratory tract infections (including ENT) e.g.tonsillitis,sinusitis,otitis media.
    • Lower respiratory tract infections e.g.acute and chronic bronchitis, lobar and bronchopneumonia.
    • Genito-urinary tract infections e.g.cystitis,urethritis,pyelonephritis.
    • Skin and soft tissue infections.
    • Bone and joint infections e.g.osteomyelitis.
    • Other infections e.g.septic abortion,puerperal sepsis,intra-abdominal sepsis etc.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Pharmacodynamic properties: Co-amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by (3-lactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus Clavulanic acid in this preparation protects Amoxicillin from degradation by (3-lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

    Pharmacokinetic properties: The pharmacokinetics of the two components of Co-amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-amoxiclav approximately doubles the serum levels achieved.
    DosageView
    Adults and children over 12 years:

    Tablet:
    • The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours.
    • For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
    Suspension:
    • Children 6-12 years: 2 teaspoonful every 8 hours.
    • Children 1-6years: 1 teaspoonful every 8 hours.
    • Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d, Treatment should not be extended beyond 14 days without review.
    Forte suspension:
    • The usual recommended daily dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections)।
    • For serious infections: 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, e.g. otitis media and sinusitis, lower respiratory infections e.g. bronchopneumonia, and urinary tract infections).
    Children of 2 to 12 years:
    Mild to moderate infections:
    • 25/3.6 mg/kg/day (Suspension)
    • 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
    • 7-12years (22-40kg) 5 ml suspension b.i.d
    Serious infections:
    • 45/6.4 mg/kg/day (Forte Suspension)
    • 2-6 years (13-21 kg) 5 ml suspension b.i.d
    • 7-12 years (22-40 kg) 10 ml suspension b.i.d
    IV Injection

    Adults-
    • Usually, 1.2 gm every 8 hours
    • Increased in more serious infections to 1.2 gm every 6 hours
    • For surgical prophylaxis: The usual dose is 1.2 gm at induction, for high risk procedures (eg. colorectal surgery) up to 2-3 gm may be given every 8 hours.
    Children-
    • 0 to 3 months: 30 mg/kg every 8 hours. (every 12 hours in the perinatal period and in premature infants.
    • 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infection to 30 mg/kg every 6 hours.
    AdministrationView
    Oral dosage form: This may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Amoxicillin and Clavulanic acid are administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Amoxicillin and Clavulanic acid should be taken at the start of the meal.

    IV injection is not suitable for intramuscular or subcutaneous administration. The reconstituted vial can be administered intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes). The contents of the content of the vial must be used within 20 minutes and thereafter any unused material should be discarded.
    Side effectsView
    Side effects, as with Amoxicillin, are uncommon and mainly of a mild and transitory nature. Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting and candidiasis have been reported, if gastrointestinal side effects occur with oral therapy, that may be reduced by taking Co-amoxiclav at the start of meals. Hepatitis and cholestatic jaundice have been reported rarely but are usually reversible. Urticarial and erythematous rashes sometimes occur. Rarely erythema multiforme, Stevens-Johnson Syndrome and exfoliative dermatitis have been reported. In common with other beta-lactam antibiotics, angioedema and anaphylaxis have been reported.
    ContraindicationsView
    History of Penicillin hypersensitivity. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Also contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.
    PrecautionsView
    Co-amoxiclav should be used with care in patients on anticoagulation therapy or with severe hepatic dysfunction. In patients with moderate or severe renal impairment, dosage should be adjusted. During the administration of a high dose of Co-amoxiclav adequate fluid intake and urinary output should be maintained to minimize the possibility of crystalluria.
    InteractionsView
    Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Co-amoxiclav. In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.
    Pregnancy & lactationView
    Animal studies with orally and parenterally administered Co-amoxiclav have shown no teratogenic effect. The drug has been used orally in human pregnancy in a limited number of cases with no untoward effect; however, the use of Co-amoxiclav in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.
    Pediatric usageView
    The dose should be adjusted in case of patients with renal impairment

    Adult:
    • Mild impairment (Creatinine clearance> 30ml/minute): No changein dosage.
    • Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly.
    • Severe impairment (Creatinine clearance <10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of this preparation and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.
    Children:
    • A similar reduction in dosage should be made for children.
    • Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
    Overdose effectsView
    Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis.
    ReconstitutionView
    IV injection: 1.2 gm IV injection can be reconstituted by dissolving the powder in 20 ml Water for Injection BP. This IV injection should not be reconstituted or mixed with: Dextrose solution, Sodium Bicarbonate solution for injection, Protein Hydrolysates or other Proteinaceous fluids, blood or plasma, Intravenous lipids. However, the reconstituted solution may be injected into the drip tubing of infusion fluids containing glucose, bicarbonate and dextran over a period of 3-4 minutes.
    StorageView
    This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.

    Amoclav

    Amoxicillin + Clavulanic Acid
    Tablet 875 mg+125 mg Allopathic Broad spectrum penicillins

    Indications

    Severe or recurrent respiratory tract infections

    Indication detailsView
    Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites:
    • Upper respiratory tract infections (including ENT) e.g.tonsillitis,sinusitis,otitis media.
    • Lower respiratory tract infections e.g.acute and chronic bronchitis, lobar and bronchopneumonia.
    • Genito-urinary tract infections e.g.cystitis,urethritis,pyelonephritis.
    • Skin and soft tissue infections.
    • Bone and joint infections e.g.osteomyelitis.
    • Other infections e.g.septic abortion,puerperal sepsis,intra-abdominal sepsis etc.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Pharmacodynamic properties: Co-amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by (3-lactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus Clavulanic acid in this preparation protects Amoxicillin from degradation by (3-lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

    Pharmacokinetic properties: The pharmacokinetics of the two components of Co-amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-amoxiclav approximately doubles the serum levels achieved.
    DosageView
    Adults and children over 12 years:

    Tablet:
    • The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours.
    • For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
    Suspension:
    • Children 6-12 years: 2 teaspoonful every 8 hours.
    • Children 1-6years: 1 teaspoonful every 8 hours.
    • Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d, Treatment should not be extended beyond 14 days without review.
    Forte suspension:
    • The usual recommended daily dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections)।
    • For serious infections: 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, e.g. otitis media and sinusitis, lower respiratory infections e.g. bronchopneumonia, and urinary tract infections).
    Children of 2 to 12 years:
    Mild to moderate infections:
    • 25/3.6 mg/kg/day (Suspension)
    • 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
    • 7-12years (22-40kg) 5 ml suspension b.i.d
    Serious infections:
    • 45/6.4 mg/kg/day (Forte Suspension)
    • 2-6 years (13-21 kg) 5 ml suspension b.i.d
    • 7-12 years (22-40 kg) 10 ml suspension b.i.d
    IV Injection

    Adults-
    • Usually, 1.2 gm every 8 hours
    • Increased in more serious infections to 1.2 gm every 6 hours
    • For surgical prophylaxis: The usual dose is 1.2 gm at induction, for high risk procedures (eg. colorectal surgery) up to 2-3 gm may be given every 8 hours.
    Children-
    • 0 to 3 months: 30 mg/kg every 8 hours. (every 12 hours in the perinatal period and in premature infants.
    • 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infection to 30 mg/kg every 6 hours.
    AdministrationView
    Oral dosage form: This may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Amoxicillin and Clavulanic acid are administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Amoxicillin and Clavulanic acid should be taken at the start of the meal.

    IV injection is not suitable for intramuscular or subcutaneous administration. The reconstituted vial can be administered intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes). The contents of the content of the vial must be used within 20 minutes and thereafter any unused material should be discarded.
    Side effectsView
    Side effects, as with Amoxicillin, are uncommon and mainly of a mild and transitory nature. Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting and candidiasis have been reported, if gastrointestinal side effects occur with oral therapy, that may be reduced by taking Co-amoxiclav at the start of meals. Hepatitis and cholestatic jaundice have been reported rarely but are usually reversible. Urticarial and erythematous rashes sometimes occur. Rarely erythema multiforme, Stevens-Johnson Syndrome and exfoliative dermatitis have been reported. In common with other beta-lactam antibiotics, angioedema and anaphylaxis have been reported.
    ContraindicationsView
    History of Penicillin hypersensitivity. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Also contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.
    PrecautionsView
    Co-amoxiclav should be used with care in patients on anticoagulation therapy or with severe hepatic dysfunction. In patients with moderate or severe renal impairment, dosage should be adjusted. During the administration of a high dose of Co-amoxiclav adequate fluid intake and urinary output should be maintained to minimize the possibility of crystalluria.
    InteractionsView
    Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Co-amoxiclav. In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.
    Pregnancy & lactationView
    Animal studies with orally and parenterally administered Co-amoxiclav have shown no teratogenic effect. The drug has been used orally in human pregnancy in a limited number of cases with no untoward effect; however, the use of Co-amoxiclav in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.
    Pediatric usageView
    The dose should be adjusted in case of patients with renal impairment

    Adult:
    • Mild impairment (Creatinine clearance> 30ml/minute): No changein dosage.
    • Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly.
    • Severe impairment (Creatinine clearance <10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of this preparation and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.
    Children:
    • A similar reduction in dosage should be made for children.
    • Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
    Overdose effectsView
    Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis.
    ReconstitutionView
    IV injection: 1.2 gm IV injection can be reconstituted by dissolving the powder in 20 ml Water for Injection BP. This IV injection should not be reconstituted or mixed with: Dextrose solution, Sodium Bicarbonate solution for injection, Protein Hydrolysates or other Proteinaceous fluids, blood or plasma, Intravenous lipids. However, the reconstituted solution may be injected into the drip tubing of infusion fluids containing glucose, bicarbonate and dextran over a period of 3-4 minutes.
    StorageView
    This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.

    Amoclav

    Amoxicillin + Clavulanic Acid
    Tablet 500 mg+125 mg Allopathic Broad spectrum penicillins

    Indications

    Severe or recurrent respiratory tract infections

    Indication detailsView
    Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites:
    • Upper respiratory tract infections (including ENT) e.g.tonsillitis,sinusitis,otitis media.
    • Lower respiratory tract infections e.g.acute and chronic bronchitis, lobar and bronchopneumonia.
    • Genito-urinary tract infections e.g.cystitis,urethritis,pyelonephritis.
    • Skin and soft tissue infections.
    • Bone and joint infections e.g.osteomyelitis.
    • Other infections e.g.septic abortion,puerperal sepsis,intra-abdominal sepsis etc.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Pharmacodynamic properties: Co-amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by (3-lactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus Clavulanic acid in this preparation protects Amoxicillin from degradation by (3-lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

    Pharmacokinetic properties: The pharmacokinetics of the two components of Co-amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-amoxiclav approximately doubles the serum levels achieved.
    DosageView
    Adults and children over 12 years:

    Tablet:
    • The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours.
    • For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
    Suspension:
    • Children 6-12 years: 2 teaspoonful every 8 hours.
    • Children 1-6years: 1 teaspoonful every 8 hours.
    • Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d, Treatment should not be extended beyond 14 days without review.
    Forte suspension:
    • The usual recommended daily dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections)।
    • For serious infections: 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, e.g. otitis media and sinusitis, lower respiratory infections e.g. bronchopneumonia, and urinary tract infections).
    Children of 2 to 12 years:
    Mild to moderate infections:
    • 25/3.6 mg/kg/day (Suspension)
    • 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
    • 7-12years (22-40kg) 5 ml suspension b.i.d
    Serious infections:
    • 45/6.4 mg/kg/day (Forte Suspension)
    • 2-6 years (13-21 kg) 5 ml suspension b.i.d
    • 7-12 years (22-40 kg) 10 ml suspension b.i.d
    IV Injection

    Adults-
    • Usually, 1.2 gm every 8 hours
    • Increased in more serious infections to 1.2 gm every 6 hours
    • For surgical prophylaxis: The usual dose is 1.2 gm at induction, for high risk procedures (eg. colorectal surgery) up to 2-3 gm may be given every 8 hours.
    Children-
    • 0 to 3 months: 30 mg/kg every 8 hours. (every 12 hours in the perinatal period and in premature infants.
    • 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infection to 30 mg/kg every 6 hours.
    AdministrationView
    Oral dosage form: This may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Amoxicillin and Clavulanic acid are administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Amoxicillin and Clavulanic acid should be taken at the start of the meal.

    IV injection is not suitable for intramuscular or subcutaneous administration. The reconstituted vial can be administered intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes). The contents of the content of the vial must be used within 20 minutes and thereafter any unused material should be discarded.
    Side effectsView
    Side effects, as with Amoxicillin, are uncommon and mainly of a mild and transitory nature. Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting and candidiasis have been reported, if gastrointestinal side effects occur with oral therapy, that may be reduced by taking Co-amoxiclav at the start of meals. Hepatitis and cholestatic jaundice have been reported rarely but are usually reversible. Urticarial and erythematous rashes sometimes occur. Rarely erythema multiforme, Stevens-Johnson Syndrome and exfoliative dermatitis have been reported. In common with other beta-lactam antibiotics, angioedema and anaphylaxis have been reported.
    ContraindicationsView
    History of Penicillin hypersensitivity. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Also contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.
    PrecautionsView
    Co-amoxiclav should be used with care in patients on anticoagulation therapy or with severe hepatic dysfunction. In patients with moderate or severe renal impairment, dosage should be adjusted. During the administration of a high dose of Co-amoxiclav adequate fluid intake and urinary output should be maintained to minimize the possibility of crystalluria.
    InteractionsView
    Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Co-amoxiclav. In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.
    Pregnancy & lactationView
    Animal studies with orally and parenterally administered Co-amoxiclav have shown no teratogenic effect. The drug has been used orally in human pregnancy in a limited number of cases with no untoward effect; however, the use of Co-amoxiclav in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.
    Pediatric usageView
    The dose should be adjusted in case of patients with renal impairment

    Adult:
    • Mild impairment (Creatinine clearance> 30ml/minute): No changein dosage.
    • Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly.
    • Severe impairment (Creatinine clearance <10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of this preparation and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.
    Children:
    • A similar reduction in dosage should be made for children.
    • Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
    Overdose effectsView
    Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis.
    ReconstitutionView
    IV injection: 1.2 gm IV injection can be reconstituted by dissolving the powder in 20 ml Water for Injection BP. This IV injection should not be reconstituted or mixed with: Dextrose solution, Sodium Bicarbonate solution for injection, Protein Hydrolysates or other Proteinaceous fluids, blood or plasma, Intravenous lipids. However, the reconstituted solution may be injected into the drip tubing of infusion fluids containing glucose, bicarbonate and dextran over a period of 3-4 minutes.
    StorageView
    This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.

    Amoclav

    Amoxicillin + Clavulanic Acid
    Powder for Suspension (125 mg+31.25 mg)/5 ml Allopathic Broad spectrum penicillins

    Indications

    Severe or recurrent respiratory tract infections

    Indication detailsView
    Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites:
    • Upper respiratory tract infections (including ENT) e.g.tonsillitis,sinusitis,otitis media.
    • Lower respiratory tract infections e.g.acute and chronic bronchitis, lobar and bronchopneumonia.
    • Genito-urinary tract infections e.g.cystitis,urethritis,pyelonephritis.
    • Skin and soft tissue infections.
    • Bone and joint infections e.g.osteomyelitis.
    • Other infections e.g.septic abortion,puerperal sepsis,intra-abdominal sepsis etc.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Pharmacodynamic properties: Co-amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by (3-lactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus Clavulanic acid in this preparation protects Amoxicillin from degradation by (3-lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

    Pharmacokinetic properties: The pharmacokinetics of the two components of Co-amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-amoxiclav approximately doubles the serum levels achieved.
    DosageView
    Adults and children over 12 years:

    Tablet:
    • The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours.
    • For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
    Suspension:
    • Children 6-12 years: 2 teaspoonful every 8 hours.
    • Children 1-6years: 1 teaspoonful every 8 hours.
    • Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d, Treatment should not be extended beyond 14 days without review.
    Forte suspension:
    • The usual recommended daily dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections)।
    • For serious infections: 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, e.g. otitis media and sinusitis, lower respiratory infections e.g. bronchopneumonia, and urinary tract infections).
    Children of 2 to 12 years:
    Mild to moderate infections:
    • 25/3.6 mg/kg/day (Suspension)
    • 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
    • 7-12years (22-40kg) 5 ml suspension b.i.d
    Serious infections:
    • 45/6.4 mg/kg/day (Forte Suspension)
    • 2-6 years (13-21 kg) 5 ml suspension b.i.d
    • 7-12 years (22-40 kg) 10 ml suspension b.i.d
    IV Injection

    Adults-
    • Usually, 1.2 gm every 8 hours
    • Increased in more serious infections to 1.2 gm every 6 hours
    • For surgical prophylaxis: The usual dose is 1.2 gm at induction, for high risk procedures (eg. colorectal surgery) up to 2-3 gm may be given every 8 hours.
    Children-
    • 0 to 3 months: 30 mg/kg every 8 hours. (every 12 hours in the perinatal period and in premature infants.
    • 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infection to 30 mg/kg every 6 hours.
    AdministrationView
    Oral dosage form: This may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Amoxicillin and Clavulanic acid are administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Amoxicillin and Clavulanic acid should be taken at the start of the meal.

    IV injection is not suitable for intramuscular or subcutaneous administration. The reconstituted vial can be administered intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes). The contents of the content of the vial must be used within 20 minutes and thereafter any unused material should be discarded.
    Side effectsView
    Side effects, as with Amoxicillin, are uncommon and mainly of a mild and transitory nature. Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting and candidiasis have been reported, if gastrointestinal side effects occur with oral therapy, that may be reduced by taking Co-amoxiclav at the start of meals. Hepatitis and cholestatic jaundice have been reported rarely but are usually reversible. Urticarial and erythematous rashes sometimes occur. Rarely erythema multiforme, Stevens-Johnson Syndrome and exfoliative dermatitis have been reported. In common with other beta-lactam antibiotics, angioedema and anaphylaxis have been reported.
    ContraindicationsView
    History of Penicillin hypersensitivity. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Also contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.
    PrecautionsView
    Co-amoxiclav should be used with care in patients on anticoagulation therapy or with severe hepatic dysfunction. In patients with moderate or severe renal impairment, dosage should be adjusted. During the administration of a high dose of Co-amoxiclav adequate fluid intake and urinary output should be maintained to minimize the possibility of crystalluria.
    InteractionsView
    Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Co-amoxiclav. In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.
    Pregnancy & lactationView
    Animal studies with orally and parenterally administered Co-amoxiclav have shown no teratogenic effect. The drug has been used orally in human pregnancy in a limited number of cases with no untoward effect; however, the use of Co-amoxiclav in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.
    Pediatric usageView
    The dose should be adjusted in case of patients with renal impairment

    Adult:
    • Mild impairment (Creatinine clearance> 30ml/minute): No changein dosage.
    • Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly.
    • Severe impairment (Creatinine clearance <10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of this preparation and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.
    Children:
    • A similar reduction in dosage should be made for children.
    • Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
    Overdose effectsView
    Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis.
    ReconstitutionView
    IV injection: 1.2 gm IV injection can be reconstituted by dissolving the powder in 20 ml Water for Injection BP. This IV injection should not be reconstituted or mixed with: Dextrose solution, Sodium Bicarbonate solution for injection, Protein Hydrolysates or other Proteinaceous fluids, blood or plasma, Intravenous lipids. However, the reconstituted solution may be injected into the drip tubing of infusion fluids containing glucose, bicarbonate and dextran over a period of 3-4 minutes.
    StorageView
    This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.

    Amoclav Forte

    Amoxicillin + Clavulanic Acid
    Powder for Suspension (400 mg+57.50 mg)/5 ml Allopathic Broad spectrum penicillins

    Indications

    Severe or recurrent respiratory tract infections

    Indication detailsView
    Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites:
    • Upper respiratory tract infections (including ENT) e.g.tonsillitis,sinusitis,otitis media.
    • Lower respiratory tract infections e.g.acute and chronic bronchitis, lobar and bronchopneumonia.
    • Genito-urinary tract infections e.g.cystitis,urethritis,pyelonephritis.
    • Skin and soft tissue infections.
    • Bone and joint infections e.g.osteomyelitis.
    • Other infections e.g.septic abortion,puerperal sepsis,intra-abdominal sepsis etc.
    Therapeutic classView
    Broad spectrum penicillins
    PharmacologyView
    Pharmacodynamic properties: Co-amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by (3-lactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus Clavulanic acid in this preparation protects Amoxicillin from degradation by (3-lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

    Pharmacokinetic properties: The pharmacokinetics of the two components of Co-amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-amoxiclav approximately doubles the serum levels achieved.
    DosageView
    Adults and children over 12 years:

    Tablet:
    • The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours.
    • For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
    Suspension:
    • Children 6-12 years: 2 teaspoonful every 8 hours.
    • Children 1-6years: 1 teaspoonful every 8 hours.
    • Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d, Treatment should not be extended beyond 14 days without review.
    Forte suspension:
    • The usual recommended daily dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections)।
    • For serious infections: 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, e.g. otitis media and sinusitis, lower respiratory infections e.g. bronchopneumonia, and urinary tract infections).
    Children of 2 to 12 years:
    Mild to moderate infections:
    • 25/3.6 mg/kg/day (Suspension)
    • 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
    • 7-12years (22-40kg) 5 ml suspension b.i.d
    Serious infections:
    • 45/6.4 mg/kg/day (Forte Suspension)
    • 2-6 years (13-21 kg) 5 ml suspension b.i.d
    • 7-12 years (22-40 kg) 10 ml suspension b.i.d
    IV Injection

    Adults-
    • Usually, 1.2 gm every 8 hours
    • Increased in more serious infections to 1.2 gm every 6 hours
    • For surgical prophylaxis: The usual dose is 1.2 gm at induction, for high risk procedures (eg. colorectal surgery) up to 2-3 gm may be given every 8 hours.
    Children-
    • 0 to 3 months: 30 mg/kg every 8 hours. (every 12 hours in the perinatal period and in premature infants.
    • 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infection to 30 mg/kg every 6 hours.
    AdministrationView
    Oral dosage form: This may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Amoxicillin and Clavulanic acid are administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Amoxicillin and Clavulanic acid should be taken at the start of the meal.

    IV injection is not suitable for intramuscular or subcutaneous administration. The reconstituted vial can be administered intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes). The contents of the content of the vial must be used within 20 minutes and thereafter any unused material should be discarded.
    Side effectsView
    Side effects, as with Amoxicillin, are uncommon and mainly of a mild and transitory nature. Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting and candidiasis have been reported, if gastrointestinal side effects occur with oral therapy, that may be reduced by taking Co-amoxiclav at the start of meals. Hepatitis and cholestatic jaundice have been reported rarely but are usually reversible. Urticarial and erythematous rashes sometimes occur. Rarely erythema multiforme, Stevens-Johnson Syndrome and exfoliative dermatitis have been reported. In common with other beta-lactam antibiotics, angioedema and anaphylaxis have been reported.
    ContraindicationsView
    History of Penicillin hypersensitivity. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Also contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.
    PrecautionsView
    Co-amoxiclav should be used with care in patients on anticoagulation therapy or with severe hepatic dysfunction. In patients with moderate or severe renal impairment, dosage should be adjusted. During the administration of a high dose of Co-amoxiclav adequate fluid intake and urinary output should be maintained to minimize the possibility of crystalluria.
    InteractionsView
    Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Co-amoxiclav. In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.
    Pregnancy & lactationView
    Animal studies with orally and parenterally administered Co-amoxiclav have shown no teratogenic effect. The drug has been used orally in human pregnancy in a limited number of cases with no untoward effect; however, the use of Co-amoxiclav in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.
    Pediatric usageView
    The dose should be adjusted in case of patients with renal impairment

    Adult:
    • Mild impairment (Creatinine clearance> 30ml/minute): No changein dosage.
    • Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly.
    • Severe impairment (Creatinine clearance <10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of this preparation and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.
    Children:
    • A similar reduction in dosage should be made for children.
    • Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
    Overdose effectsView
    Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis.
    ReconstitutionView
    IV injection: 1.2 gm IV injection can be reconstituted by dissolving the powder in 20 ml Water for Injection BP. This IV injection should not be reconstituted or mixed with: Dextrose solution, Sodium Bicarbonate solution for injection, Protein Hydrolysates or other Proteinaceous fluids, blood or plasma, Intravenous lipids. However, the reconstituted solution may be injected into the drip tubing of infusion fluids containing glucose, bicarbonate and dextran over a period of 3-4 minutes.
    StorageView
    This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.